Treatment with short-term, high-dose cyclosporin A in children with refractory chronic idiopathic thrombocytopenic purpura

Silverio Perrotta, Giovanni Amendola, Franco Locatelli, Maria Luisa Conte, Francesca Rossi, Giovanna d'Urzo, Bruno Nobili

Research output: Contribution to journalArticle

Abstract

We report on 14 children (seven boys, seven girls) with chronic idiopathic thrombocytopenic purpura (ITP) refractory to multiple treatments, who were given a short-term therapy (range between 6 and 10 weeks) with high doses of cyclosporin A (CyA) (median, 10 mg/kg/d). Six patients experienced adverse events and one developed severe systemic mycosis during therapy. A complete response (CR) was observed in four patients and a partial response (PR) in three patients. Only the four CR patients, who were all girls, had a sustained response. These data suggest that CyA may be effective in some children with chronic symptomatic ITP.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalBritish Journal of Haematology
Volume121
Issue number1
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Children
  • Cyclosporine
  • Idiopathic thrombocytopenic purpura
  • Lymphocyte immunophenotype
  • Platelet

ASJC Scopus subject areas

  • Hematology

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