Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years

Sara Grignolo, Paola Tatarelli, Giulia Gustinetti, Francesca Viazzi, Barbara Bonino, Paolo Maggi, Claudio Viscoli, Antonio Di Biagio

Research output: Contribution to journalArticle

Abstract

The aim of this study is to describe longitudinal changes in estimated glomerular filtration rate (eGFR) in a cohort of mother-to-child HIV-infected adolescents exposed to tenofovir dixoproxil fumarate (TDF) for at least 2 years. We retrospectively examined eGFR at starting TDF (T0), at 24 months (T2) and at the final assessment (T3). Twenty-nine patients were studied. The mean duration of TDF exposure was 67 months (24–123). At baseline, the mean eGFR was 152 ml/min/1.73 m2 (105–227, SD, 33). There was a significant decrease of eGFR from a mean of 152 ml/min/1.73 m2 (SD, 33) at T0 to 140 ml/min/1.73 m2 (SD, 33) at T2 and 123 ml/min/1.73 m2 (SD, 14) at T3. The decrease of eGFR was significant, with ΔGFR (T3-T0) of −29 ml/min/1.73 m2 (SD, 30; p <0.0001) and a mean ΔGFR per year of −6 and ml/min/1.73 m2 (SD, 8). Conclusion: We noted a long-term decline in eGFR in this small cohort of mother-to-child HIV-infected adolescents receiving TDF-containing cART, even if the lack of a control group and the small sample size are major limitations.

Original languageEnglish
Pages (from-to)843-846
Number of pages4
JournalEuropean Journal of Pediatrics
Volume174
Issue number6
DOIs
Publication statusPublished - Dec 16 2014

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Tenofovir
Glomerular Filtration Rate
Fumarates
Mothers
HIV
Sample Size

Keywords

  • Complications of antiretroviral therapy
  • Paediatric HIV
  • Renal disease
  • Tenofovir

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Grignolo, S., Tatarelli, P., Gustinetti, G., Viazzi, F., Bonino, B., Maggi, P., ... Di Biagio, A. (2014). Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years. European Journal of Pediatrics, 174(6), 843-846. https://doi.org/10.1007/s00431-014-2468-2

Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years. / Grignolo, Sara; Tatarelli, Paola; Gustinetti, Giulia; Viazzi, Francesca; Bonino, Barbara; Maggi, Paolo; Viscoli, Claudio; Di Biagio, Antonio.

In: European Journal of Pediatrics, Vol. 174, No. 6, 16.12.2014, p. 843-846.

Research output: Contribution to journalArticle

Grignolo, Sara ; Tatarelli, Paola ; Gustinetti, Giulia ; Viazzi, Francesca ; Bonino, Barbara ; Maggi, Paolo ; Viscoli, Claudio ; Di Biagio, Antonio. / Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years. In: European Journal of Pediatrics. 2014 ; Vol. 174, No. 6. pp. 843-846.
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AB - The aim of this study is to describe longitudinal changes in estimated glomerular filtration rate (eGFR) in a cohort of mother-to-child HIV-infected adolescents exposed to tenofovir dixoproxil fumarate (TDF) for at least 2 years. We retrospectively examined eGFR at starting TDF (T0), at 24 months (T2) and at the final assessment (T3). Twenty-nine patients were studied. The mean duration of TDF exposure was 67 months (24–123). At baseline, the mean eGFR was 152 ml/min/1.73 m2 (105–227, SD, 33). There was a significant decrease of eGFR from a mean of 152 ml/min/1.73 m2 (SD, 33) at T0 to 140 ml/min/1.73 m2 (SD, 33) at T2 and 123 ml/min/1.73 m2 (SD, 14) at T3. The decrease of eGFR was significant, with ΔGFR (T3-T0) of −29 ml/min/1.73 m2 (SD, 30; p <0.0001) and a mean ΔGFR per year of −6 and ml/min/1.73 m2 (SD, 8). Conclusion: We noted a long-term decline in eGFR in this small cohort of mother-to-child HIV-infected adolescents receiving TDF-containing cART, even if the lack of a control group and the small sample size are major limitations.

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