Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years

Sara Grignolo, Paola Tatarelli, Giulia Gustinetti, Francesca Viazzi, Barbara Bonino, Paolo Maggi, Claudio Viscoli, Antonio Di Biagio

Research output: Contribution to journalArticle

Abstract

The aim of this study is to describe longitudinal changes in estimated glomerular filtration rate (eGFR) in a cohort of mother-to-child HIV-infected adolescents exposed to tenofovir dixoproxil fumarate (TDF) for at least 2 years. We retrospectively examined eGFR at starting TDF (T0), at 24 months (T2) and at the final assessment (T3). Twenty-nine patients were studied. The mean duration of TDF exposure was 67 months (24–123). At baseline, the mean eGFR was 152 ml/min/1.73 m2 (105–227, SD, 33). There was a significant decrease of eGFR from a mean of 152 ml/min/1.73 m2 (SD, 33) at T0 to 140 ml/min/1.73 m2 (SD, 33) at T2 and 123 ml/min/1.73 m2 (SD, 14) at T3. The decrease of eGFR was significant, with ΔGFR (T3-T0) of −29 ml/min/1.73 m2 (SD, 30; p <0.0001) and a mean ΔGFR per year of −6 and ml/min/1.73 m2 (SD, 8). Conclusion: We noted a long-term decline in eGFR in this small cohort of mother-to-child HIV-infected adolescents receiving TDF-containing cART, even if the lack of a control group and the small sample size are major limitations.

Original languageEnglish
Pages (from-to)843-846
Number of pages4
JournalEuropean Journal of Pediatrics
Volume174
Issue number6
DOIs
Publication statusPublished - Dec 16 2014

Keywords

  • Complications of antiretroviral therapy
  • Paediatric HIV
  • Renal disease
  • Tenofovir

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Grignolo, S., Tatarelli, P., Gustinetti, G., Viazzi, F., Bonino, B., Maggi, P., Viscoli, C., & Di Biagio, A. (2014). Trend of eGFR in an Italian cohort of mother-to-child HIV-infected patients exposed to tenofovir for at least 2 years. European Journal of Pediatrics, 174(6), 843-846. https://doi.org/10.1007/s00431-014-2468-2