Trends and determinants of calcium antagonist usage after acute myocardial infarction (the GISSI experience)

Giulio Zuanetti, Roberto Latini, Fausto Avanzini, Maria Grazia Franzosi, Aldo P. Maggioni, Fabio Colombo, Enrico Nicolis, Francesco Mauri

Research output: Contribution to journalArticle


In the last decade, several clinical trials in patients with, or recovering from, acute myocardial infarction (AMI) have evaluated the role of calcium antagonists in affecting patients' prognosis. Results have been disparate, with evidence of possible harm, no effect, or some benefit, depending on the agent used. We evaluated how the evidence from these trials has influenced the pattern of prescription of calcium antagonists and assessed the important determinants of use of these agents in patients after AMI. We analyzed retrospectively the prescription of calcium antagonists at discharge in all patients recovering from AMI enrolled in 3 large randomized clinical trials (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-1 [GISSI-1], GISSI-2, and GISSI-3) during the last 10 years. A progressive decrease in prescriptions for calcium antagonists was evident, from 47.2% in GISSI-1 to 35.1% in GISSI-2 to 19.0% in GISSI-3 (p

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalThe American Journal of Cardiology
Issue number2
Publication statusPublished - Jul 15 1996


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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