TY - JOUR
T1 - Trends in biomedical engineering
T2 - Focus on smart bio-materials and drug delivery
AU - Tanzi, Maria Cristina
AU - Bozzini, Sabrina
AU - Candiani, Gabriele
AU - Cigada, Alberto
AU - de Nardo, Luigi
AU - Farè, Silvia
AU - Ganazzoli, Fabio
AU - Gastaldi, Dario
AU - Levi, Marinella
AU - Metrangolo, Pierangelo
AU - Migliavacca, Francesco
AU - Osellame, Roberto
AU - Petrini, Paola
AU - Raffaini, Giuseppina
AU - Resnati, Giuseppe
AU - Vena, Pasquale
AU - Vesentini, Simone
AU - Zunino, Paolo
PY - 2011/5
Y1 - 2011/5
N2 - The present article reviews on different research lines, namely: drug and gene delivery, surface modification/modeling, design of advanced materials (shape memory polymers and biodegradable stents), presently developed at Politecnico di Milano, Italy. For gene delivery, non-viral polycationic-branched polyethylenimine (b-PEI) polyplexes are coated with pectin, an anionic polysaccharide, to enhance the polyplex stability and decrease b-PEI cytotoxicity. Perfluorinated materials, specifically perfluoroether, and perfluoro-polyether fluids are proposed as ultrasound contrast agents and smart agents for drug delivery. Non-fouling, self-assembled PEG-based monolayers are developed on titanium surfaces with the aim of drastically reducing cariogenic bacteria adhesion on dental implants. Femtosecond laser microfabrication is used for selectively and spatially tuning the wettability of polymeric biomaterials and the effects of femtosecond laser ablation on the surface properties of polymethylmethacrylate are studied. Innovative functionally graded Alumina-Ti coatings for wear resistant articulating surfaces are deposited with PLD and characterized by means of a combined experimental and computational approach. Protein adsorption on biomaterials surfaces with an unlike wettability and surface-modification induced by pre-adsorbed proteins are studied by atomistic computer simulations. A study was performed on the fabrication of porous Shape Memory Polymeric structures and on the assessment of their potential application in minimally invasive surgical procedures. A model of magnesium (alloys) degradation, in a finite element framework analysis, and a bottom-up multiscale analysis for modeling the degradation mechanism of PLA matrices was developed, with the aim of providing valuable tools for the design of bioresorbable stents.
AB - The present article reviews on different research lines, namely: drug and gene delivery, surface modification/modeling, design of advanced materials (shape memory polymers and biodegradable stents), presently developed at Politecnico di Milano, Italy. For gene delivery, non-viral polycationic-branched polyethylenimine (b-PEI) polyplexes are coated with pectin, an anionic polysaccharide, to enhance the polyplex stability and decrease b-PEI cytotoxicity. Perfluorinated materials, specifically perfluoroether, and perfluoro-polyether fluids are proposed as ultrasound contrast agents and smart agents for drug delivery. Non-fouling, self-assembled PEG-based monolayers are developed on titanium surfaces with the aim of drastically reducing cariogenic bacteria adhesion on dental implants. Femtosecond laser microfabrication is used for selectively and spatially tuning the wettability of polymeric biomaterials and the effects of femtosecond laser ablation on the surface properties of polymethylmethacrylate are studied. Innovative functionally graded Alumina-Ti coatings for wear resistant articulating surfaces are deposited with PLD and characterized by means of a combined experimental and computational approach. Protein adsorption on biomaterials surfaces with an unlike wettability and surface-modification induced by pre-adsorbed proteins are studied by atomistic computer simulations. A study was performed on the fabrication of porous Shape Memory Polymeric structures and on the assessment of their potential application in minimally invasive surgical procedures. A model of magnesium (alloys) degradation, in a finite element framework analysis, and a bottom-up multiscale analysis for modeling the degradation mechanism of PLA matrices was developed, with the aim of providing valuable tools for the design of bioresorbable stents.
KW - Biodegradable stents
KW - Drug delivery
KW - Gene delivery
KW - Modification
KW - Shape memory polymers
KW - Surface
KW - Surface modeling
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UR - http://www.scopus.com/inward/citedby.url?scp=79960973339&partnerID=8YFLogxK
U2 - 10.5301/JABB.2011.8563
DO - 10.5301/JABB.2011.8563
M3 - Article
C2 - 22065386
AN - SCOPUS:79960973339
VL - 9
SP - 87
EP - 97
JO - Journal of Applied Biomaterials and Biomechanics
JF - Journal of Applied Biomaterials and Biomechanics
SN - 1722-6899
IS - 2
ER -