Trends in frequency and in vitro antifungal susceptibility patterns of Candida isolates from women attending the STD outpatients clinic of a tertiary care hospital in Northern Italy during the years 2002-2007

Sara Asticcioli, Laura Sacco, Rossana Daturi, Cecilia Matti, Elisabetta Nucleo, Francesca Zara, Laura Pagani

Research output: Contribution to journalArticle

Abstract

Vulvovaginal candidiasis is a common mucosal infection caused by saprophytic and opportunistic yeasts belonging to the Candida genus. 518 vaginal swabs, with positive fungal culture were collected from unselected women attending the Sexually Transmitted Disease clinic of an Italian tertiary care hospital over a six year period to determine the pathogen prevalence in vulvovaginal candidiasis and to evaluate in vitro the antifungal susceptibilities of yeast recovered by Sensititre YeastOne antifungal panel plates according to CLSI document M27-A2. The isolates belonging to the genus Candida were 495 (95.5%) with Candida albicans percentage equal to 61.2%. Voriconazole was highly active (MIC50 0.008; MIC90 0.5 uμg/ml), regardless of the species tested. On the contrary, fluconazole susceptibility was based upon the species. The intrinsic resistance to fluconazole of C. kmsei was confirmed.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalNew Microbiologica
Volume32
Issue number2
Publication statusPublished - Apr 2009

Keywords

  • Antifungal susceptibility
  • Candida
  • Vulvovaginal candidiasis

ASJC Scopus subject areas

  • Microbiology (medical)

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