Trends in hypertension control and left ventricular hypertrophy over three years

Cesare Cuspidi, Iassen Michev, Stefano Meani, Barbara Severgnini, Veronica Fusi, Maurizio Salerno, Christiana Valerio, Fabio Magrini, Alberto Zanchetti

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Background. The aim of this study was to describe trends in blood pressure (BP) control and in the prevalence of left ventricular hypertrophy (LVH) during 3 years of follow-up in a representative sample of treated hypertensive patients seen in our out-patient hypertension hospital clinic. Methods. Four hundred and sixty-four hypertensive treated patients who took part in a clinical survey at our out-patient clinic during the year 1997 and who had been submitted to a routine follow-up visit 3 years later were included in the study. All patients were subjected to the following procedures: an accurate medical history, physical examination, electrocardiogram, clinical BP measurement. For the diagnosis of LVH we used two different ECG criteria: the Solokow-Lyon voltage and the gender-specific Cornell voltage. Results. During the first survey, 15 % of treated patients had a clinical BP <130/85 mmHg, 25.1 % ≥ 130/85 mmHg and <140/90 mmHg, 33.6% ≥ 140/90 and <150/95 mmHg, 26.3% ≥ 150/95 mmHg. The corresponding figures in the second survey were 19,26.7,33.2 and 21.1 %, respectively. Overall, from the first to the second survey the prevalence of an effective BP control (<140/90 mmHg) rose from 40.1 to 46.7 % (p<0.01). At baseline, 40 patients had ECG LVH (8.6 %); at the second visit, LVH was found to have regressed in 19 of these patients. Among the 424 patients with a normal baseline electrocardiogram, 3 developed LVH during follow-up. Hence, the prevalence of LVH decreased from 8.6 to 5.1 % (p <0.01). In terms of treatment, the prevalence of combination therapy regimens increased from 68.6 to 79.7% (p <0.05). Conclusions. This study demonstrates that in hypertensive patients managed in a hypertension hospital clinic, BP control improved during the long-term follow-up and that this trend was associated with a significant regression in ECG LVH.

Original languageEnglish
Pages (from-to)514-519
Number of pages6
JournalItalian Heart Journal
Issue number9
Publication statusPublished - Sep 1 2002


  • Blood pressure
  • Hypertension
  • Hypertrophy
  • Left ventricular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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