Trends in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections

Effect of the MRSA "search and isolate" strategy in a hospital in Italy with hyperendemic MRSA

Angelo Pan, Giuseppe Carnevale, Patrizia Catenazzi, Paolo Colombini, Luciano Crema, Lucia Dolcetti, Lucio Ferrari, Placido Mondello, Liana Signorini, Carmine Tinelli, Eugenia Quiros Roldan, Giampiero Carosi

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the secular trends in MRSA BSIs after the introduction of a nosocomial MRSA control intervention. DESIGN: Before-after study. SETTING: An 850-bed community hospital with an ICU and vascular surgery, neurosurgery, bone marrow transplantation, and AIDS units. MRSA is endemic at this hospital; the prevalence of methicillin resistance among patients with S. aureus infection is greater than 50%. PATIENTS: Among all inpatients, MRSA BSI was identified, its origin defined, and incidence rates calculated by ward and origin. INTERVENTION: A MRSA control program was implemented based on active surveillance cultures to identify MRSA-colonized patients, followed by isolation using contact precautions. Incidence rates of MRSA BSI during the intervention (ie, July 1, 1997, to December 31, 2001) and preintervention (ie, January 1, 1996, to June 30, 1997) periods were compared. RESULTS: Sixty-nine MRSA BSIs were identified. When compared with the preintervention period, the incidence rate of MRSA BSI was reduced from 0.64 to 0.30 per 1,000 admissions (RR, 0.46; CI95, 0.25-0.87; P = .02) during the intervention period. The impact was greater in the ICU, with an 89% reduction (RR, 0.11; CI95, 0.01-0.98; P = .03), and for CVC-associated MRSA BSIs, with an 82% decrease (RR, 0.17; CI95, 0.05-0.55; P = .002). Methicillin resistance among S. aureus blood isolates decreased from 46% to 17% (RR, 0.36; CI95, 0.22-0.62; P= .0002). CONCLUSION: A reduction in MRSA bacteremia is achievable through use of the MRSA "search and isolate" intervention even in a hospital with high rates of endemic MRSA.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalInfection Control and Hospital Epidemiology
Volume26
Issue number2
DOIs
Publication statusPublished - Feb 2005

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Methicillin-Resistant Staphylococcus aureus
Italy
Infection
Methicillin Resistance
Staphylococcus aureus
Incidence
Patient Isolation
Community Hospital
Neurosurgery
Bacteremia
Bone Marrow Transplantation
Blood Vessels
Inpatients
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology

Cite this

Trends in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections : Effect of the MRSA "search and isolate" strategy in a hospital in Italy with hyperendemic MRSA. / Pan, Angelo; Carnevale, Giuseppe; Catenazzi, Patrizia; Colombini, Paolo; Crema, Luciano; Dolcetti, Lucia; Ferrari, Lucio; Mondello, Placido; Signorini, Liana; Tinelli, Carmine; Roldan, Eugenia Quiros; Carosi, Giampiero.

In: Infection Control and Hospital Epidemiology, Vol. 26, No. 2, 02.2005, p. 127-133.

Research output: Contribution to journalArticle

Pan, A, Carnevale, G, Catenazzi, P, Colombini, P, Crema, L, Dolcetti, L, Ferrari, L, Mondello, P, Signorini, L, Tinelli, C, Roldan, EQ & Carosi, G 2005, 'Trends in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections: Effect of the MRSA "search and isolate" strategy in a hospital in Italy with hyperendemic MRSA', Infection Control and Hospital Epidemiology, vol. 26, no. 2, pp. 127-133. https://doi.org/10.1086/502515
Pan, Angelo ; Carnevale, Giuseppe ; Catenazzi, Patrizia ; Colombini, Paolo ; Crema, Luciano ; Dolcetti, Lucia ; Ferrari, Lucio ; Mondello, Placido ; Signorini, Liana ; Tinelli, Carmine ; Roldan, Eugenia Quiros ; Carosi, Giampiero. / Trends in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections : Effect of the MRSA "search and isolate" strategy in a hospital in Italy with hyperendemic MRSA. In: Infection Control and Hospital Epidemiology. 2005 ; Vol. 26, No. 2. pp. 127-133.
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abstract = "OBJECTIVE: To evaluate the secular trends in MRSA BSIs after the introduction of a nosocomial MRSA control intervention. DESIGN: Before-after study. SETTING: An 850-bed community hospital with an ICU and vascular surgery, neurosurgery, bone marrow transplantation, and AIDS units. MRSA is endemic at this hospital; the prevalence of methicillin resistance among patients with S. aureus infection is greater than 50{\%}. PATIENTS: Among all inpatients, MRSA BSI was identified, its origin defined, and incidence rates calculated by ward and origin. INTERVENTION: A MRSA control program was implemented based on active surveillance cultures to identify MRSA-colonized patients, followed by isolation using contact precautions. Incidence rates of MRSA BSI during the intervention (ie, July 1, 1997, to December 31, 2001) and preintervention (ie, January 1, 1996, to June 30, 1997) periods were compared. RESULTS: Sixty-nine MRSA BSIs were identified. When compared with the preintervention period, the incidence rate of MRSA BSI was reduced from 0.64 to 0.30 per 1,000 admissions (RR, 0.46; CI95, 0.25-0.87; P = .02) during the intervention period. The impact was greater in the ICU, with an 89{\%} reduction (RR, 0.11; CI95, 0.01-0.98; P = .03), and for CVC-associated MRSA BSIs, with an 82{\%} decrease (RR, 0.17; CI95, 0.05-0.55; P = .002). Methicillin resistance among S. aureus blood isolates decreased from 46{\%} to 17{\%} (RR, 0.36; CI95, 0.22-0.62; P= .0002). CONCLUSION: A reduction in MRSA bacteremia is achievable through use of the MRSA {"}search and isolate{"} intervention even in a hospital with high rates of endemic MRSA.",
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AU - Pan, Angelo

AU - Carnevale, Giuseppe

AU - Catenazzi, Patrizia

AU - Colombini, Paolo

AU - Crema, Luciano

AU - Dolcetti, Lucia

AU - Ferrari, Lucio

AU - Mondello, Placido

AU - Signorini, Liana

AU - Tinelli, Carmine

AU - Roldan, Eugenia Quiros

AU - Carosi, Giampiero

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N2 - OBJECTIVE: To evaluate the secular trends in MRSA BSIs after the introduction of a nosocomial MRSA control intervention. DESIGN: Before-after study. SETTING: An 850-bed community hospital with an ICU and vascular surgery, neurosurgery, bone marrow transplantation, and AIDS units. MRSA is endemic at this hospital; the prevalence of methicillin resistance among patients with S. aureus infection is greater than 50%. PATIENTS: Among all inpatients, MRSA BSI was identified, its origin defined, and incidence rates calculated by ward and origin. INTERVENTION: A MRSA control program was implemented based on active surveillance cultures to identify MRSA-colonized patients, followed by isolation using contact precautions. Incidence rates of MRSA BSI during the intervention (ie, July 1, 1997, to December 31, 2001) and preintervention (ie, January 1, 1996, to June 30, 1997) periods were compared. RESULTS: Sixty-nine MRSA BSIs were identified. When compared with the preintervention period, the incidence rate of MRSA BSI was reduced from 0.64 to 0.30 per 1,000 admissions (RR, 0.46; CI95, 0.25-0.87; P = .02) during the intervention period. The impact was greater in the ICU, with an 89% reduction (RR, 0.11; CI95, 0.01-0.98; P = .03), and for CVC-associated MRSA BSIs, with an 82% decrease (RR, 0.17; CI95, 0.05-0.55; P = .002). Methicillin resistance among S. aureus blood isolates decreased from 46% to 17% (RR, 0.36; CI95, 0.22-0.62; P= .0002). CONCLUSION: A reduction in MRSA bacteremia is achievable through use of the MRSA "search and isolate" intervention even in a hospital with high rates of endemic MRSA.

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