Trends in oesophageal cancer incidence and mortality in Europe

Cristina Bosetti, Fabio Levi, Jacques Ferlay, Werner Garavello, Franca Lucchini, Paola Bertuccio, Eva Negri, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review

Abstract

To monitor recent trends in mortality from oesophageal cancer in 33 European countries, we analyzed the data provided by the World Health Organization over the last 2 decades, using also joinpoint regression. For selected European cancer registration areas, we also analyzed incidence rates for different histological types. For men in the European Union (EU), age-standardized (world population) mortality rates were stable around 6/100,000 between the early 1980s and the early 1990s, and slightly declined in the last decade (5.4/100,000 in the early 2000s, annual percent change, APC = -1.1%). In several western European countries, male rates have started to level off or decline during the last decade (APC = -3.4% in France, and -3.0% in Italy). Also in Spain and the UK, which showed upward trends in the 1990s, the rates tended to level off in most recent years. A levelling of rates was observed only more recently in countries of central and eastern Europe, which had had substantial rises up to the late 1990s. Oesophageal cancer mortality rates remained comparatively low in European women, and overall EU female rates were stable around 1.1-1.2/100,000 over the last 2 decades (APC = -0.1%). In northern Europe a clear upward trend was observed in the incidence of oesophageal adenocarcinoma, and in Denmark and Scotland incidence of adenocarcinoma in men is now higher than that of squamous-cell carcinoma. Squamous-cell carcinoma remained the prevalent histological type in southern Europe. Changes in smoking habits and alcohol drinking for men, and perhaps nutrition, diet and physical activity for both sexes, can partly or largely explain these trends.

Original languageEnglish
Pages (from-to)1118-1129
Number of pages12
JournalInternational Journal of Cancer
Volume122
Issue number5
DOIs
Publication statusPublished - Mar 1 2008

Keywords

  • Europe
  • Histologic types
  • Incidence
  • Mortality
  • Oesophageal cancer trends

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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