Trends in outcome after transfemoral transcatheter aortic valve implantation

Nicolas M. Van Mieghem, Alaide Chieffo, Nicolas Dumonteil, Didier Tchetche, Robert M A Van Der Boon, Gill L. Buchanan, Bertrand Marcheix, Olivier Vahdat, Patrick W. Serruys, Jean Fajadet, Didier Carrié, Antonio Colombo, Peter P T De Jaegere

Research output: Contribution to journalArticlepeer-review


Background Transfemoral transcatheter aortic valve implantation (TF-TAVI) is a viable and safe treatment strategy for patients with symptomatic severe aortic stenosis and high operative risk and has been introduced as such in the recently updated European guidelines on the management of valvular heart disease.Our aim was to assess trends in outcome after TF-TAVI. Methods Propensity score-matched analysis of a multicenter registry of consecutive patients undergoing TF-TAVI subdivided into 3 tertiles based on enrollment date was performed. Three tertiles of 214 propensity score-matched patients were compared. Results With mounting experience and moving from the initial to the last cohort, procedural contrast volume and radiation time decreased. Over time, there were less major vascular complications (15% vs 7.9%, P =.023), life-threatening bleedings (17.8% vs 7.9%, P =.003), and major bleedings (22.4% vs 12.1%, P =.007). Major vascular complications and life-threatening bleedings caused by closure device failure decreased significantly (9.2% vs 3.1% [P =.01] and 5.7% vs 1 % [P =.01], respectively). The combined safety end point dropped from 31.3% in tertile (T) (T1) to 17.8% in T3 (P

Original languageEnglish
Pages (from-to)183-192
Number of pages10
JournalAmerican Heart Journal
Issue number2
Publication statusPublished - Feb 2013


  • Abbreviations
  • acute kidney injury
  • AKI
  • aortic stenosis
  • AS
  • CABG
  • coronary artery bypass grafting
  • relative risk reduction
  • RRR
  • SAVR
  • surgical aortic valve replacement
  • T
  • TAVI
  • tertile
  • TF
  • transcatheter aortic valve implantation
  • transfemoral

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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