Trials in the elderly

Emilio Perucca, Alan Richens

Research output: Contribution to journalArticlepeer-review


Epilepsy in the elderly differs from that in younger people in several respects. The incidence of seizures increases sharply with age and the seizures are more often symptomatic of underlying brain disease. The handling of antiepileptic drugs (AEDs) may be impaired by diminishing hepatic and renal function as age advances, and the pharmacodynamic response to drug therapy may be altered. In consequence, the elderly are more likely to experience adverse drug effects. Whether their seizures respond to drug treatment in a different way from younger patients is uncertain, but there are, nevertheless, convincing arguments for clinical trials being undertaken specifically in this population during the Phase II/IV development programme.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalEpilepsy Research
Issue number1-3
Publication statusPublished - 2001


  • Antiepileptic drugs
  • Clinical trials
  • Elderly

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology


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