Triazolam and melatonin effects on cardiac autonomic function during sleep

L. Ferini-Strambi, A. Oldani, M. Zucconi, B. Stankov, C. Castronovo, F. Fraschini, S. Smirne

Research output: Contribution to journalArticle

Abstract

After benzodiazepine (BDZ) administration, a decrease in cardiac vagal tone has been described during wakefulness, but data on cardiac autonomic function during sleep are lacking. Melatonin (MLT), reported to have hypnotic properties, caused an increase in vagal tone in animals. The aim of this study was to evaluate heart rate (HR) variability during sleep after a single bedtime dose of triazolam (TRI, 0.125 mg) and MLT (100 mg) in six healthy young subjects. We evaluated tonic (vagal activity) HR modifications in relation to sleep, as well as phasic (sympathetic activity) HR modifications in relation to spontaneous body movements during rapid-eye-movement (REM) and non-REM (NREM) sleep. No significant change in sympathetic activity was observed after TRI and MLT in comparison with placebo, whereas TRI caused a significant decrease in vagal tone during sleep. Our nocturnal study seems to confirm previous diurnal findings about a decrease in vagal tone by BDZs.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalClinical Neuropharmacology
Volume18
Issue number5
Publication statusPublished - 1995

Keywords

  • Cardiac autonomic system
  • Melatonin
  • Sleep
  • Triazolam

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Ferini-Strambi, L., Oldani, A., Zucconi, M., Stankov, B., Castronovo, C., Fraschini, F., & Smirne, S. (1995). Triazolam and melatonin effects on cardiac autonomic function during sleep. Clinical Neuropharmacology, 18(5), 405-409.