TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion

S. Prudente, R. Baratta, F. Andreozzi, E. Morini, M. G. Farina, A. Nigro, M. Copetti, F. Pellegrini, E. Succurro, L. Di Pietrantonio, C. Brufani, F. Barbetti, B. Dallapiccola, G. Sesti, V. Trischitta, L. Frittitta

Research output: Contribution to journalArticlepeer-review

Abstract

Aims/hypothesis The results of studies on the genetics of complex traits need to be replicated and to reach robust statistical significance before they can be considered as established. We here tried to replicate the previously reported association between the TRIB3 Q84R polymorphism (rs2295490) and glucose homeostasis. Methods Three samples of Europeans with fasting glucose -1kg-1, p=0.022, in QQ, QR and RR individuals, respectively. Conclusions/interpretation Our data confirm that the TRIB3 R84 variant affects glucose homeostasis and suggest this effect is due to an alteration of the interplay between insulin sensitivity and secretion.

Original languageEnglish
Pages (from-to)1354-1361
Number of pages8
JournalDiabetologia
Volume53
Issue number7
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Akt
  • Early type 2 diabetes
  • Inhibitors of insulin signalling

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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