Abstract
Trichloroethylene (TCE), a synthetic compound widely used in many occupational and non-occupational settings, is one of the leading environmental contaminants. In this paper, current information on sources, human exposure, metabolism, toxicology and health impact of TCE is reviewed. The central nervous system is the major target for TCE toxicity. This compound, however, can also exert toxic effects on other tissues and organs, for example the myocardium, the kidney and the liver. Several rodent bioassays indicate that TCE is a carcinogen for laboratory animals. Human carcinogenicity, however, is still controversial as there are limited epidemiological studies available for assessment and important species differences in metabolism that make extrapolation from animal studies more challenging. Current regulatory standards are discussed in connection with the analysis of technical and medical prevention.
| Original language | English |
|---|---|
| Pages (from-to) | 17-25 |
| Number of pages | 9 |
| Journal | Giornale Italiano di Medicina del Lavoro |
| Volume | 13 |
| Issue number | 1-6 |
| Publication status | Published - Jan 1991 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Rehabilitation
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Trichloroethylene : toxicology and health hazards. / Candura, S. M.; Faustman, E. M.
In: Giornale Italiano di Medicina del Lavoro, Vol. 13, No. 1-6, 01.1991, p. 17-25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trichloroethylene
T2 - toxicology and health hazards.
AU - Candura, S. M.
AU - Faustman, E. M.
PY - 1991/1
Y1 - 1991/1
N2 - Trichloroethylene (TCE), a synthetic compound widely used in many occupational and non-occupational settings, is one of the leading environmental contaminants. In this paper, current information on sources, human exposure, metabolism, toxicology and health impact of TCE is reviewed. The central nervous system is the major target for TCE toxicity. This compound, however, can also exert toxic effects on other tissues and organs, for example the myocardium, the kidney and the liver. Several rodent bioassays indicate that TCE is a carcinogen for laboratory animals. Human carcinogenicity, however, is still controversial as there are limited epidemiological studies available for assessment and important species differences in metabolism that make extrapolation from animal studies more challenging. Current regulatory standards are discussed in connection with the analysis of technical and medical prevention.
AB - Trichloroethylene (TCE), a synthetic compound widely used in many occupational and non-occupational settings, is one of the leading environmental contaminants. In this paper, current information on sources, human exposure, metabolism, toxicology and health impact of TCE is reviewed. The central nervous system is the major target for TCE toxicity. This compound, however, can also exert toxic effects on other tissues and organs, for example the myocardium, the kidney and the liver. Several rodent bioassays indicate that TCE is a carcinogen for laboratory animals. Human carcinogenicity, however, is still controversial as there are limited epidemiological studies available for assessment and important species differences in metabolism that make extrapolation from animal studies more challenging. Current regulatory standards are discussed in connection with the analysis of technical and medical prevention.
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M3 - Article
C2 - 1845454
AN - SCOPUS:0025926266
VL - 13
SP - 17
EP - 25
JO - Giornale Italiano di Medicina del Lavoro
JF - Giornale Italiano di Medicina del Lavoro
SN - 0391-9889
IS - 1-6
ER -