Trichomonas vaginalis: Effect of tinidazole on ultrastructure in vitro

G. Carosi; G. Filice; F. Suter; A. Dei Cas

doi:10.1016/0014-4894(77)90036-4

Trichomonas vaginalis: Effect of tinidazole on ultrastructure in vitro

G. Carosi, G. Filice, F. Suter, A. Dei Cas

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Low concentrations of tinidazole, 1.2 to 1.8 μg/ml, were added for periods of 1 to 6 hr to cultures of recently isolated Trichomonas vaginalis strains. The first ultrastructural changes seen in electron micrographs occurred after 1 and 3 hr with alterations of the matrix of the hydrogenosomes and degranulation of glycogen. After 6 hr, there were degenerative changes of the endoplasmic reticulum and Golgi apparatus. The morphology of the nucleus and the mastigont remained unaltered.

Original language	English
Pages (from-to)	315-325
Number of pages	11
Journal	Experimental Parasitology
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/0014-4894(77)90036-4
Publication status	Published - 1977

Keywords

Anaerobic metabolism
Electron microscopy
Hydrogenosomes
In vitro drug action
Nitroimidazoles
Parasitic protozoa
Tinidazole
Trichomonas vaginalis
Ultrastructural changes

ASJC Scopus subject areas

Immunology
Parasitology
Infectious Diseases

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title = "Trichomonas vaginalis: Effect of tinidazole on ultrastructure in vitro",

abstract = "Low concentrations of tinidazole, 1.2 to 1.8 μg/ml, were added for periods of 1 to 6 hr to cultures of recently isolated Trichomonas vaginalis strains. The first ultrastructural changes seen in electron micrographs occurred after 1 and 3 hr with alterations of the matrix of the hydrogenosomes and degranulation of glycogen. After 6 hr, there were degenerative changes of the endoplasmic reticulum and Golgi apparatus. The morphology of the nucleus and the mastigont remained unaltered.",

keywords = "Anaerobic metabolism, Electron microscopy, Hydrogenosomes, In vitro drug action, Nitroimidazoles, Parasitic protozoa, Tinidazole, Trichomonas vaginalis, Ultrastructural changes",

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year = "1977",

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T2 - Effect of tinidazole on ultrastructure in vitro

AU - Carosi, G.

AU - Filice, G.

AU - Suter, F.

AU - Dei Cas, A.

PY - 1977

Y1 - 1977

N2 - Low concentrations of tinidazole, 1.2 to 1.8 μg/ml, were added for periods of 1 to 6 hr to cultures of recently isolated Trichomonas vaginalis strains. The first ultrastructural changes seen in electron micrographs occurred after 1 and 3 hr with alterations of the matrix of the hydrogenosomes and degranulation of glycogen. After 6 hr, there were degenerative changes of the endoplasmic reticulum and Golgi apparatus. The morphology of the nucleus and the mastigont remained unaltered.

AB - Low concentrations of tinidazole, 1.2 to 1.8 μg/ml, were added for periods of 1 to 6 hr to cultures of recently isolated Trichomonas vaginalis strains. The first ultrastructural changes seen in electron micrographs occurred after 1 and 3 hr with alterations of the matrix of the hydrogenosomes and degranulation of glycogen. After 6 hr, there were degenerative changes of the endoplasmic reticulum and Golgi apparatus. The morphology of the nucleus and the mastigont remained unaltered.

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KW - Electron microscopy

KW - Hydrogenosomes

KW - In vitro drug action

KW - Nitroimidazoles

KW - Parasitic protozoa

KW - Tinidazole

KW - Trichomonas vaginalis

KW - Ultrastructural changes

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Trichomonas vaginalis: Effect of tinidazole on ultrastructure in vitro

Abstract

Keywords

ASJC Scopus subject areas

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