Trichomonas vaginalis: Effect of tinidazole on ultrastructure in vitro

G. Carosi, G. Filice, F. Suter, A. Dei Cas

Research output: Contribution to journalArticlepeer-review

Abstract

Low concentrations of tinidazole, 1.2 to 1.8 μg/ml, were added for periods of 1 to 6 hr to cultures of recently isolated Trichomonas vaginalis strains. The first ultrastructural changes seen in electron micrographs occurred after 1 and 3 hr with alterations of the matrix of the hydrogenosomes and degranulation of glycogen. After 6 hr, there were degenerative changes of the endoplasmic reticulum and Golgi apparatus. The morphology of the nucleus and the mastigont remained unaltered.

Original languageEnglish
Pages (from-to)315-325
Number of pages11
JournalExperimental Parasitology
Volume43
Issue number2
DOIs
Publication statusPublished - 1977

Keywords

  • Anaerobic metabolism
  • Electron microscopy
  • Hydrogenosomes
  • In vitro drug action
  • Nitroimidazoles
  • Parasitic protozoa
  • Tinidazole
  • Trichomonas vaginalis
  • Ultrastructural changes

ASJC Scopus subject areas

  • Immunology
  • Parasitology
  • Infectious Diseases

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