Trichostatin A blocks type I interferon production by activated plasmacytoid dendritic cells

Valentina Salvi, Daniela Bosisio, Stefania Mitola, Laura Andreoli, Angela Tincani, Silvano Sozzani

Research output: Contribution to journalArticlepeer-review

Abstract

Plasmacytoid dendritic cells (PDC) represent the main type I interferon (IFN-I) producing cells. Emerging evidence supports a role for IFN-I in autoimmune diseases. Given the central role of PDC in the pathogenesis of systemic lupus erythematosus (SLE), we investigated the effect of Trichostatin A (TSA), a prototypic histone deacetylase inhibitor, on PDC activation. TSA inhibited the production of IFN-I, TRAIL and of the pro-inflammatory cytokines TNFα and IL-6 by CpG-activated PDC. These effects were associated with the inhibition of IFN Regulatory Factor (IRF)-7 nuclear translocation. Furthermore, TSA was also effective in inhibiting the production of IFNα by PDC cultured in vitro in the presence of serum obtained from SLE patients. This study describes a new level of regulation of immune responses by histone deacetylase inhibitors and defines the molecular basis for new strategies to be exploited in the treatment of autoimmune diseases.

Original languageEnglish
Pages (from-to)756-761
Number of pages6
JournalImmunobiology
Volume215
Issue number9-10
DOIs
Publication statusPublished - Sep 2010

Keywords

  • Autoimmunity
  • Cytokines
  • HDAC
  • Interferon
  • Plasmacytoid dendritic cells

ASJC Scopus subject areas

  • Immunology
  • Hematology
  • Immunology and Allergy

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