Abstract
Plasmacytoid dendritic cells (PDC) represent the main type I interferon (IFN-I) producing cells. Emerging evidence supports a role for IFN-I in autoimmune diseases. Given the central role of PDC in the pathogenesis of systemic lupus erythematosus (SLE), we investigated the effect of Trichostatin A (TSA), a prototypic histone deacetylase inhibitor, on PDC activation. TSA inhibited the production of IFN-I, TRAIL and of the pro-inflammatory cytokines TNFα and IL-6 by CpG-activated PDC. These effects were associated with the inhibition of IFN Regulatory Factor (IRF)-7 nuclear translocation. Furthermore, TSA was also effective in inhibiting the production of IFNα by PDC cultured in vitro in the presence of serum obtained from SLE patients. This study describes a new level of regulation of immune responses by histone deacetylase inhibitors and defines the molecular basis for new strategies to be exploited in the treatment of autoimmune diseases.
Original language | English |
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Pages (from-to) | 756-761 |
Number of pages | 6 |
Journal | Immunobiology |
Volume | 215 |
Issue number | 9-10 |
DOIs | |
Publication status | Published - Sep 2010 |
Keywords
- Autoimmunity
- Cytokines
- HDAC
- Interferon
- Plasmacytoid dendritic cells
ASJC Scopus subject areas
- Immunology
- Hematology
- Immunology and Allergy