Tricuspid annuloplasty versus a conservative approach in patients with functional tricuspid regurgitation undergoing left-sided heart valve surgery: A study-level meta-analysis

M. Pagnesi, C. Montalto, A. Mangieri, E. Agricola, R. Puri, M. Chiarito, M.B. Ancona, D. Regazzoli, L. Testa, M. De Bonis, N.E. Moat, J. Rodés-Cabau, A. Colombo, A. Latib

Research output: Contribution to journalArticle


Background Tricuspid valve (TV) repair at the time of left-sided valve surgery is indicated in patients with either severe functional tricuspid regurgitation (TR) or mild-to-moderate TR with coexistent tricuspid annular dilation or right heart failure. We assessed the benefits of a concomitant TV repair strategy during left-sided surgical valve interventions, focusing on mortality and echocardiographic TR-related outcomes. Methods A meta-analysis was performed of studies reporting outcomes of patients who underwent left-sided (mitral and/or aortic) valve surgery with or without concomitant TV repair. Primary endpoints were all-cause and cardiac-related mortality; secondary endpoints were the presence of more-than-moderate TR, TR progression, and TR severity grade. All endpoints were evaluated at the longest available follow-up. Results Fifteen studies were included for a total of 2840 patients. TV repair at the time of left-sided valve surgery was associated with a significantly lower risk of cardiac-related mortality (odds ratio [OR] 0.38; 95% confidence interval [CI]: 0.25–0.58; p 
Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalInternational Journal of Cardiology
Publication statusPublished - 2017



  • Cardiac surgery
  • Meta-analysis
  • Tricuspid annuloplasty
  • Tricuspid regurgitation
  • Tricuspid valve repair
  • Valvular heart disease
  • aortic valve repair
  • Article
  • cardiovascular mortality
  • cause of death
  • clinical outcome
  • conservative treatment
  • disease severity
  • echocardiography
  • follow up
  • human
  • intermethod comparison
  • meta analysis
  • mitral valve surgery
  • mortality rate
  • mortality risk
  • priority journal
  • prognosis
  • randomized controlled trial (topic)
  • risk assessment
  • survival rate
  • trend study
  • tricuspid annuloplasty
  • tricuspid valve regurgitation
  • tricuspid valve repair

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