Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity

G. Cignarella, D. Barlocco, S. Villa, MM Curzu, GA Pinna, A. Lavezzo, A. Bestetti

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new series of benzopyranopyridazinones (1b-e) either unsubstituted at the amide nitrogen or substituted by an alkyl thiourea, as well as two benzocinnolinone derivatives (2b, f) have been synthesized and tested for their antiulcer and antisecretory activity. All the test compounds showed statistically significant antiulcer properties in the EtOH model, 1b being the most active. On the contrary, in the ASA model only 1b and 1d were found weakly active. In the pylorus-ligated rat model, 1b and 1e displayed significant antisecretory activity, though only 1b proved to be able to reduce the acidity of the gastric secretion.

Original languageEnglish
Pages (from-to)819-823
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume27
Issue number8
DOIs
Publication statusPublished - 1992

Fingerprint

Thiourea
Pylorus
Amides
Stomach
Nitrogen
Derivatives
Acidity
Rats

Keywords

  • antisecretory activity
  • antiulcer activity
  • pyridazinones

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity. / Cignarella, G.; Barlocco, D.; Villa, S.; Curzu, MM; Pinna, GA; Lavezzo, A.; Bestetti, A.

In: European Journal of Medicinal Chemistry, Vol. 27, No. 8, 1992, p. 819-823.

Research output: Contribution to journalArticle

Cignarella, G. ; Barlocco, D. ; Villa, S. ; Curzu, MM ; Pinna, GA ; Lavezzo, A. ; Bestetti, A. / Tricyclic 3-(2H)-pyridazinone derivatives. Synthesis and evaluation of their antisecretory and antiulcer activity. In: European Journal of Medicinal Chemistry. 1992 ; Vol. 27, No. 8. pp. 819-823.
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