Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects

Alice De Corato, Lucia Lisi, Alessandro Capuano, Giuseppe Tringali, Antonella Tramutola, Pierluigi Navarra, Cinzia Dello Russo

Research output: Contribution to journalArticlepeer-review

Abstract

Calcitonin gene-related peptide (CGRP) is the main mediator of trigeminal pain signal. Functional CGRP receptors were detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. CGRP displayed modest pro-inflammatory effects per se on trigeminal satellite cells, while it significantly enhanced IL-1β actions, increasing the expression and activity of cycloxygenase 2 as well as the expression of the inducible form of nitric oxide synthase and IL-1β. CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalJournal of Neuroimmunology
Volume237
Issue number1-2
DOIs
Publication statusPublished - Aug 15 2011

Keywords

  • CGRP
  • Cortical astrocytes
  • IL1β
  • Migraine
  • Proinflammatory genes
  • Trigeminal satellite cells

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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