Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects

Alice De Corato, Lucia Lisi, Alessandro Capuano, Giuseppe Tringali, Antonella Tramutola, Pierluigi Navarra, Cinzia Dello Russo

Research output: Contribution to journalArticle

Abstract

Calcitonin gene-related peptide (CGRP) is the main mediator of trigeminal pain signal. Functional CGRP receptors were detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. CGRP displayed modest pro-inflammatory effects per se on trigeminal satellite cells, while it significantly enhanced IL-1β actions, increasing the expression and activity of cycloxygenase 2 as well as the expression of the inducible form of nitric oxide synthase and IL-1β. CGRP effects were reverted by a specific CGRP receptor antagonist and mimicked by elevation of intracellular cAMP levels. CGRP exerted also minor proinflammatory effects on cortical astrocytes.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalJournal of Neuroimmunology
Volume237
Issue number1-2
DOIs
Publication statusPublished - Aug 15 2011

Fingerprint

Calcitonin Gene-Related Peptide Receptors
Calcitonin Gene-Related Peptide
Interleukin-1
Sensory Ganglia
Nitric Oxide Synthase Type II
Neuroglia
Astrocytes
Pain

Keywords

  • CGRP
  • Cortical astrocytes
  • IL1β
  • Migraine
  • Proinflammatory genes
  • Trigeminal satellite cells

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects. / De Corato, Alice; Lisi, Lucia; Capuano, Alessandro; Tringali, Giuseppe; Tramutola, Antonella; Navarra, Pierluigi; Dello Russo, Cinzia.

In: Journal of Neuroimmunology, Vol. 237, No. 1-2, 15.08.2011, p. 39-46.

Research output: Contribution to journalArticle

De Corato, Alice ; Lisi, Lucia ; Capuano, Alessandro ; Tringali, Giuseppe ; Tramutola, Antonella ; Navarra, Pierluigi ; Dello Russo, Cinzia. / Trigeminal satellite cells express functional calcitonin gene-related peptide receptors, whose activation enhances interleukin-1β pro-inflammatory effects. In: Journal of Neuroimmunology. 2011 ; Vol. 237, No. 1-2. pp. 39-46.
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