Triglycerides-to-HDL cholesterol ratio as screening tool for impaired glucose tolerance in obese children and adolescents

Melania Manco, Graziano Grugni, M. Di Pietro, A. Balsamo, Stefania Di Candia, Giuseppe Stefano Morino, A. Franzese, P. Di Bonito, C. Maffeis, Giuliana Valerio

Research output: Contribution to journalArticle

Abstract

Aims: To identify metabolic phenotypes at increased risk of impaired glucose tolerance (IGT) in Italian overweight/obese children (n = 148, age 5–10 years) and adolescents (n = 531, age 10–17.9 year). Methods: Phenotypes were defined as follows: obesity by the 95th cut-points of the Center for Disease Control body mass index reference standards, impaired fasting glucose (fasting plasma glucose ≥100 mg/dl), high circulating triglycerides (TG), TG/HDL cholesterol ≥2.2, waist-to-height ratio (WTHR) >0.6, and combination of the latter with high TG or TG/HDL cholesterol ≥2.2. Results: In the 148 obese children, TG/HDL-C ≥ 2.2 (OR 20.19; 95 % CI 2.50–163.28, p = 0.005) and the combination of TG/HDL-C ≥ 2.2 and WTHR > 0.60 (OR 14.97; 95 % CI 2.18–102.76, p = 0.006) were significantly associated with IGT. In the 531 adolescents, TG/HDL-C ≥ 2.2 (OR 1.991; 95 % CI 1.243–3.191, p = 0.004) and the combination with WTHR > 0.60 (OR 2.24; 95 % CI 1.29–3.87, p = 0.004) were associated with significantly increased risk of IGT. In the whole sample, having high TG levels according to the NIH National Heart, Lung and Blood Institute Expert Panel was not associated with an increased risk of presenting IGT. Conclusions: TG/HDL-C ratio can be useful, particularly in children, to identify obese young patients at risk of IGT. Its accuracy as screening tool in a general population needs to be verified. The combination of TG/HDL-C ratio and WTHR > 0.6 did not improve prediction. Having high TG according to the NIH definition was not associated with increased risk of developing IGT.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalActa Diabetologica
Volume53
Issue number3
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Glucose Intolerance
HDL Cholesterol
Triglycerides
Fasting
National Heart, Lung, and Blood Institute (U.S.)
Phenotype
Glucose
Centers for Disease Control and Prevention (U.S.)
Body Mass Index
Obesity

Keywords

  • Children
  • Impaired glucose tolerance
  • Pediatric obesity
  • Triglycerides-to-HDL cholesterol ratio
  • Waist

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Triglycerides-to-HDL cholesterol ratio as screening tool for impaired glucose tolerance in obese children and adolescents. / Manco, Melania; Grugni, Graziano; Di Pietro, M.; Balsamo, A.; Di Candia, Stefania; Morino, Giuseppe Stefano; Franzese, A.; Di Bonito, P.; Maffeis, C.; Valerio, Giuliana.

In: Acta Diabetologica, Vol. 53, No. 3, 01.06.2016, p. 493-498.

Research output: Contribution to journalArticle

Manco, Melania ; Grugni, Graziano ; Di Pietro, M. ; Balsamo, A. ; Di Candia, Stefania ; Morino, Giuseppe Stefano ; Franzese, A. ; Di Bonito, P. ; Maffeis, C. ; Valerio, Giuliana. / Triglycerides-to-HDL cholesterol ratio as screening tool for impaired glucose tolerance in obese children and adolescents. In: Acta Diabetologica. 2016 ; Vol. 53, No. 3. pp. 493-498.
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abstract = "Aims: To identify metabolic phenotypes at increased risk of impaired glucose tolerance (IGT) in Italian overweight/obese children (n = 148, age 5–10 years) and adolescents (n = 531, age 10–17.9 year). Methods: Phenotypes were defined as follows: obesity by the 95th cut-points of the Center for Disease Control body mass index reference standards, impaired fasting glucose (fasting plasma glucose ≥100 mg/dl), high circulating triglycerides (TG), TG/HDL cholesterol ≥2.2, waist-to-height ratio (WTHR) >0.6, and combination of the latter with high TG or TG/HDL cholesterol ≥2.2. Results: In the 148 obese children, TG/HDL-C ≥ 2.2 (OR 20.19; 95 {\%} CI 2.50–163.28, p = 0.005) and the combination of TG/HDL-C ≥ 2.2 and WTHR > 0.60 (OR 14.97; 95 {\%} CI 2.18–102.76, p = 0.006) were significantly associated with IGT. In the 531 adolescents, TG/HDL-C ≥ 2.2 (OR 1.991; 95 {\%} CI 1.243–3.191, p = 0.004) and the combination with WTHR > 0.60 (OR 2.24; 95 {\%} CI 1.29–3.87, p = 0.004) were associated with significantly increased risk of IGT. In the whole sample, having high TG levels according to the NIH National Heart, Lung and Blood Institute Expert Panel was not associated with an increased risk of presenting IGT. Conclusions: TG/HDL-C ratio can be useful, particularly in children, to identify obese young patients at risk of IGT. Its accuracy as screening tool in a general population needs to be verified. The combination of TG/HDL-C ratio and WTHR > 0.6 did not improve prediction. Having high TG according to the NIH definition was not associated with increased risk of developing IGT.",
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AU - Manco, Melania

AU - Grugni, Graziano

AU - Di Pietro, M.

AU - Balsamo, A.

AU - Di Candia, Stefania

AU - Morino, Giuseppe Stefano

AU - Franzese, A.

AU - Di Bonito, P.

AU - Maffeis, C.

AU - Valerio, Giuliana

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N2 - Aims: To identify metabolic phenotypes at increased risk of impaired glucose tolerance (IGT) in Italian overweight/obese children (n = 148, age 5–10 years) and adolescents (n = 531, age 10–17.9 year). Methods: Phenotypes were defined as follows: obesity by the 95th cut-points of the Center for Disease Control body mass index reference standards, impaired fasting glucose (fasting plasma glucose ≥100 mg/dl), high circulating triglycerides (TG), TG/HDL cholesterol ≥2.2, waist-to-height ratio (WTHR) >0.6, and combination of the latter with high TG or TG/HDL cholesterol ≥2.2. Results: In the 148 obese children, TG/HDL-C ≥ 2.2 (OR 20.19; 95 % CI 2.50–163.28, p = 0.005) and the combination of TG/HDL-C ≥ 2.2 and WTHR > 0.60 (OR 14.97; 95 % CI 2.18–102.76, p = 0.006) were significantly associated with IGT. In the 531 adolescents, TG/HDL-C ≥ 2.2 (OR 1.991; 95 % CI 1.243–3.191, p = 0.004) and the combination with WTHR > 0.60 (OR 2.24; 95 % CI 1.29–3.87, p = 0.004) were associated with significantly increased risk of IGT. In the whole sample, having high TG levels according to the NIH National Heart, Lung and Blood Institute Expert Panel was not associated with an increased risk of presenting IGT. Conclusions: TG/HDL-C ratio can be useful, particularly in children, to identify obese young patients at risk of IGT. Its accuracy as screening tool in a general population needs to be verified. The combination of TG/HDL-C ratio and WTHR > 0.6 did not improve prediction. Having high TG according to the NIH definition was not associated with increased risk of developing IGT.

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