Triiodothyronine-induced shortening of chromatin repeat length in neurons cultured in a chemically defined medium

Alessandro Cestelli, Italia Di Liegro, Daniele Castiglia, Roberto Gristina, Donatella Ferraro, Giuseppe Salemi, Giovanni Savettieri

Research output: Contribution to journalArticlepeer-review

Abstract

At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ~200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one.

Original languageEnglish
Pages (from-to)1053-1059
Number of pages7
JournalJournal of Neurochemistry
Volume48
Issue number4
DOIs
Publication statusPublished - 1987

Keywords

  • Chemically defined medium
  • Chromatin structure
  • Neuronal terminal differentiation
  • Triiodothyronine

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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