TRIM proteins in cancer

Valeria Cambiaghi, Virginia Giuliani, Sara Lombardi, Cristiano Marinelli, Francesca Toffalorio, Pier Giuseppe Pelicci

Research output: Chapter in Book/Report/Conference proceedingChapter

58 Citations (Scopus)

Abstract

Some members of the tripartite motif (TRIM/RBCC) protein family are thought to be important regulators of carcinogenesis. This is not surprising as the TRIM proteins are involved in several biological processes, such as cell growth, development and cellular differentiation and alteration of these proteins can affect transcriptional regulation, cell proliferation and apoptosis. In particular, four TRIM family genes are frequently translocated to other genes, generating fusion proteins implicated in cancer initiation and progression. Among these the most famous is the promy elocytic leukaemia gene PML, which encodes the protein TRIM19. PML is involved in the t(15;17) translocation that specifically occurs in Acute Promyelocytic Leukaemia (APL), resulting in a PML-retinoic acid receptor-a (PML-RARα) fusion protein. Other members of the TRIM family are linked to cancer development without being involved in chromosomal re-arrangements, possibly through ubiquitination or loss of tumour suppression functions. This chapter discusses the biological functions of TRIM proteins in cancer.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages77-91
Number of pages15
Volume770
DOIs
Publication statusPublished - 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume770
ISSN (Print)00652598

Fingerprint

Neoplasms
Proteins
Biological Phenomena
Genes
Acute Promyelocytic Leukemia
Retinoic Acid Receptors
Gene Fusion
Ubiquitination
Growth and Development
Fusion reactions
Carcinogenesis
Leukemia
Cell Proliferation
Apoptosis
Cell proliferation
Cell growth
Tripartite Motif Proteins
Tumors
Promyelocytic Leukemia Protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Cambiaghi, V., Giuliani, V., Lombardi, S., Marinelli, C., Toffalorio, F., & Pelicci, P. G. (2012). TRIM proteins in cancer. In Advances in Experimental Medicine and Biology (Vol. 770, pp. 77-91). (Advances in Experimental Medicine and Biology; Vol. 770). https://doi.org/10.1007/978-1-4614-5398-7_6

TRIM proteins in cancer. / Cambiaghi, Valeria; Giuliani, Virginia; Lombardi, Sara; Marinelli, Cristiano; Toffalorio, Francesca; Pelicci, Pier Giuseppe.

Advances in Experimental Medicine and Biology. Vol. 770 2012. p. 77-91 (Advances in Experimental Medicine and Biology; Vol. 770).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cambiaghi, V, Giuliani, V, Lombardi, S, Marinelli, C, Toffalorio, F & Pelicci, PG 2012, TRIM proteins in cancer. in Advances in Experimental Medicine and Biology. vol. 770, Advances in Experimental Medicine and Biology, vol. 770, pp. 77-91. https://doi.org/10.1007/978-1-4614-5398-7_6
Cambiaghi V, Giuliani V, Lombardi S, Marinelli C, Toffalorio F, Pelicci PG. TRIM proteins in cancer. In Advances in Experimental Medicine and Biology. Vol. 770. 2012. p. 77-91. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-5398-7_6
Cambiaghi, Valeria ; Giuliani, Virginia ; Lombardi, Sara ; Marinelli, Cristiano ; Toffalorio, Francesca ; Pelicci, Pier Giuseppe. / TRIM proteins in cancer. Advances in Experimental Medicine and Biology. Vol. 770 2012. pp. 77-91 (Advances in Experimental Medicine and Biology).
@inbook{b6cf6f44542a4cd0ac2f5343b1d105d1,
title = "TRIM proteins in cancer",
abstract = "Some members of the tripartite motif (TRIM/RBCC) protein family are thought to be important regulators of carcinogenesis. This is not surprising as the TRIM proteins are involved in several biological processes, such as cell growth, development and cellular differentiation and alteration of these proteins can affect transcriptional regulation, cell proliferation and apoptosis. In particular, four TRIM family genes are frequently translocated to other genes, generating fusion proteins implicated in cancer initiation and progression. Among these the most famous is the promy elocytic leukaemia gene PML, which encodes the protein TRIM19. PML is involved in the t(15;17) translocation that specifically occurs in Acute Promyelocytic Leukaemia (APL), resulting in a PML-retinoic acid receptor-a (PML-RARα) fusion protein. Other members of the TRIM family are linked to cancer development without being involved in chromosomal re-arrangements, possibly through ubiquitination or loss of tumour suppression functions. This chapter discusses the biological functions of TRIM proteins in cancer.",
author = "Valeria Cambiaghi and Virginia Giuliani and Sara Lombardi and Cristiano Marinelli and Francesca Toffalorio and Pelicci, {Pier Giuseppe}",
year = "2012",
doi = "10.1007/978-1-4614-5398-7_6",
language = "English",
isbn = "9781461453970",
volume = "770",
series = "Advances in Experimental Medicine and Biology",
pages = "77--91",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - TRIM proteins in cancer

AU - Cambiaghi, Valeria

AU - Giuliani, Virginia

AU - Lombardi, Sara

AU - Marinelli, Cristiano

AU - Toffalorio, Francesca

AU - Pelicci, Pier Giuseppe

PY - 2012

Y1 - 2012

N2 - Some members of the tripartite motif (TRIM/RBCC) protein family are thought to be important regulators of carcinogenesis. This is not surprising as the TRIM proteins are involved in several biological processes, such as cell growth, development and cellular differentiation and alteration of these proteins can affect transcriptional regulation, cell proliferation and apoptosis. In particular, four TRIM family genes are frequently translocated to other genes, generating fusion proteins implicated in cancer initiation and progression. Among these the most famous is the promy elocytic leukaemia gene PML, which encodes the protein TRIM19. PML is involved in the t(15;17) translocation that specifically occurs in Acute Promyelocytic Leukaemia (APL), resulting in a PML-retinoic acid receptor-a (PML-RARα) fusion protein. Other members of the TRIM family are linked to cancer development without being involved in chromosomal re-arrangements, possibly through ubiquitination or loss of tumour suppression functions. This chapter discusses the biological functions of TRIM proteins in cancer.

AB - Some members of the tripartite motif (TRIM/RBCC) protein family are thought to be important regulators of carcinogenesis. This is not surprising as the TRIM proteins are involved in several biological processes, such as cell growth, development and cellular differentiation and alteration of these proteins can affect transcriptional regulation, cell proliferation and apoptosis. In particular, four TRIM family genes are frequently translocated to other genes, generating fusion proteins implicated in cancer initiation and progression. Among these the most famous is the promy elocytic leukaemia gene PML, which encodes the protein TRIM19. PML is involved in the t(15;17) translocation that specifically occurs in Acute Promyelocytic Leukaemia (APL), resulting in a PML-retinoic acid receptor-a (PML-RARα) fusion protein. Other members of the TRIM family are linked to cancer development without being involved in chromosomal re-arrangements, possibly through ubiquitination or loss of tumour suppression functions. This chapter discusses the biological functions of TRIM proteins in cancer.

UR - http://www.scopus.com/inward/record.url?scp=84878904155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878904155&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-5398-7_6

DO - 10.1007/978-1-4614-5398-7_6

M3 - Chapter

C2 - 23631001

AN - SCOPUS:84878904155

SN - 9781461453970

VL - 770

T3 - Advances in Experimental Medicine and Biology

SP - 77

EP - 91

BT - Advances in Experimental Medicine and Biology

ER -