TriMatch comparison of the efficacy of FloSeal versus TachoSil versus no hemostatic agents for partial nephrectomy: Results from a large multicenter dataset

Alessandro Antonelli, Andrea Minervini, Andrea Mari, Riccardo Bertolo, Giampaolo Bianchi, Alberto Lapini, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Giuseppe Morgia, Giacomo Novara, Francesco Porpiglia, Bernardo Rocco, Bruno Rovereto, Riccardo Schiavina, Claudio Simeone, Mario Sodano, Carlo Terrone, Vincenzo Ficarra, Marco CariniSergio Serni

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: To evaluate the efficacy of hemostatic agents, TachoSil and FloSeal, during partial nephrectomy using a large multicenter dataset. Methods: Data of 1055 patients who underwent partial nephrectomy between January 2009 and December 2012 in 19 Italian centers were collected within an observational multicentric study (RECORd Project). The decision whether or not to use hemostatic agents after renorrhaphy and the type of hemostatic agents applied was adopted according to the centers' and surgeons' preference. A TriMatch propensity score analysis was applied to balance three study groups (no hemostatic agents, TachoSil, FloSeal) for sex, age, surgical indication (elective/relative vs imperative), clinical stage (cT1avscT1b), tumor exophyticity, approach (open vs minimally invasive), technique (standard partial nephrectomy vs simple enucleation), preoperative hemoglobin and creatinine. Postoperative complications and variation of hemoglobin and creatinine values between preoperative versus third postoperative day were compared. Results: TriMatch analysis allowed us to obtain 66 well-balanced triplets. No differences were found in terms of outcomes between the study groups. Conclusions: The present findings suggest that adding hemostatic agents to renorraphy during partial nephrectomy does not provide better surgical outcomes.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalInternational Journal of Urology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Hemostatics
Nephrectomy
Creatinine
Hemoglobins
Propensity Score
Observational Studies
Outcome Assessment (Health Care)
Datasets
TachoSil
Neoplasms

Keywords

  • Bleeding
  • Complications
  • Hemostasis
  • Hemostatic agent
  • Partial nephrectomy

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

TriMatch comparison of the efficacy of FloSeal versus TachoSil versus no hemostatic agents for partial nephrectomy : Results from a large multicenter dataset. / Antonelli, Alessandro; Minervini, Andrea; Mari, Andrea; Bertolo, Riccardo; Bianchi, Giampaolo; Lapini, Alberto; Longo, Nicola; Martorana, Giuseppe; Mirone, Vincenzo; Morgia, Giuseppe; Novara, Giacomo; Porpiglia, Francesco; Rocco, Bernardo; Rovereto, Bruno; Schiavina, Riccardo; Simeone, Claudio; Sodano, Mario; Terrone, Carlo; Ficarra, Vincenzo; Carini, Marco; Serni, Sergio.

In: International Journal of Urology, Vol. 22, No. 1, 01.01.2015, p. 47-52.

Research output: Contribution to journalArticle

Antonelli, A, Minervini, A, Mari, A, Bertolo, R, Bianchi, G, Lapini, A, Longo, N, Martorana, G, Mirone, V, Morgia, G, Novara, G, Porpiglia, F, Rocco, B, Rovereto, B, Schiavina, R, Simeone, C, Sodano, M, Terrone, C, Ficarra, V, Carini, M & Serni, S 2015, 'TriMatch comparison of the efficacy of FloSeal versus TachoSil versus no hemostatic agents for partial nephrectomy: Results from a large multicenter dataset', International Journal of Urology, vol. 22, no. 1, pp. 47-52. https://doi.org/10.1111/iju.12603
Antonelli, Alessandro ; Minervini, Andrea ; Mari, Andrea ; Bertolo, Riccardo ; Bianchi, Giampaolo ; Lapini, Alberto ; Longo, Nicola ; Martorana, Giuseppe ; Mirone, Vincenzo ; Morgia, Giuseppe ; Novara, Giacomo ; Porpiglia, Francesco ; Rocco, Bernardo ; Rovereto, Bruno ; Schiavina, Riccardo ; Simeone, Claudio ; Sodano, Mario ; Terrone, Carlo ; Ficarra, Vincenzo ; Carini, Marco ; Serni, Sergio. / TriMatch comparison of the efficacy of FloSeal versus TachoSil versus no hemostatic agents for partial nephrectomy : Results from a large multicenter dataset. In: International Journal of Urology. 2015 ; Vol. 22, No. 1. pp. 47-52.
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AU - Bertolo, Riccardo

AU - Bianchi, Giampaolo

AU - Lapini, Alberto

AU - Longo, Nicola

AU - Martorana, Giuseppe

AU - Mirone, Vincenzo

AU - Morgia, Giuseppe

AU - Novara, Giacomo

AU - Porpiglia, Francesco

AU - Rocco, Bernardo

AU - Rovereto, Bruno

AU - Schiavina, Riccardo

AU - Simeone, Claudio

AU - Sodano, Mario

AU - Terrone, Carlo

AU - Ficarra, Vincenzo

AU - Carini, Marco

AU - Serni, Sergio

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N2 - Objectives: To evaluate the efficacy of hemostatic agents, TachoSil and FloSeal, during partial nephrectomy using a large multicenter dataset. Methods: Data of 1055 patients who underwent partial nephrectomy between January 2009 and December 2012 in 19 Italian centers were collected within an observational multicentric study (RECORd Project). The decision whether or not to use hemostatic agents after renorrhaphy and the type of hemostatic agents applied was adopted according to the centers' and surgeons' preference. A TriMatch propensity score analysis was applied to balance three study groups (no hemostatic agents, TachoSil, FloSeal) for sex, age, surgical indication (elective/relative vs imperative), clinical stage (cT1avscT1b), tumor exophyticity, approach (open vs minimally invasive), technique (standard partial nephrectomy vs simple enucleation), preoperative hemoglobin and creatinine. Postoperative complications and variation of hemoglobin and creatinine values between preoperative versus third postoperative day were compared. Results: TriMatch analysis allowed us to obtain 66 well-balanced triplets. No differences were found in terms of outcomes between the study groups. Conclusions: The present findings suggest that adding hemostatic agents to renorraphy during partial nephrectomy does not provide better surgical outcomes.

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