Triphenyl tin hepatotoxicity in rats

A. Di Nucci, C. Gregotti, L. Manzo

Research output: Contribution to journalArticle

Abstract

Hepatic microsomal aniline hydroxylase and aminopyrine N-demethylase in vitro activities and the biliary excretion of sulfobromophthalein (BSP) were significantly reduced in rats treated with triphenyl tin (TPT) in daily doses of 1 mg/kg i.p. for 3 days. Bile flow, liver weight, serum enzyme activities, and hepatic sulfhydryl groups and thiobarbituric reactant levels were unaffected in TPT-treated animals. Moreover, TPT failed to induce any appreciable change in the biliary excretion of both the organic base procainamide ethobromide and the organic acid amaranth which is excreted into the bile in the unmetabolized form. TPT has been shown to be an effective inhibitor of rat liver glutathione-S-transferase activity. Reduced conjugation with glutathione may play a role as a factor determining the low rate of biliary BSP excretion in the TPT-treated rats.

Original languageEnglish
Pages (from-to)402-405
Number of pages4
JournalArchives of Toxicology
Volume59
Issue numberSUPPL. 9
Publication statusPublished - 1986

Fingerprint

Tin
Rats
Sulfobromophthalein
Liver
Bile
Aminopyrine N-Demethylase
Aniline Hydroxylase
Organic acids
Enzyme activity
Glutathione Transferase
Glutathione
Animals
Weights and Measures
Acids
Enzymes
Serum
Hepatobiliary Elimination

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Medicine(all)
  • Toxicology

Cite this

Di Nucci, A., Gregotti, C., & Manzo, L. (1986). Triphenyl tin hepatotoxicity in rats. Archives of Toxicology, 59(SUPPL. 9), 402-405.

Triphenyl tin hepatotoxicity in rats. / Di Nucci, A.; Gregotti, C.; Manzo, L.

In: Archives of Toxicology, Vol. 59, No. SUPPL. 9, 1986, p. 402-405.

Research output: Contribution to journalArticle

Di Nucci, A, Gregotti, C & Manzo, L 1986, 'Triphenyl tin hepatotoxicity in rats', Archives of Toxicology, vol. 59, no. SUPPL. 9, pp. 402-405.
Di Nucci A, Gregotti C, Manzo L. Triphenyl tin hepatotoxicity in rats. Archives of Toxicology. 1986;59(SUPPL. 9):402-405.
Di Nucci, A. ; Gregotti, C. ; Manzo, L. / Triphenyl tin hepatotoxicity in rats. In: Archives of Toxicology. 1986 ; Vol. 59, No. SUPPL. 9. pp. 402-405.
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