Triple combination antimicrobial regimen in the treatment of infections of neutropenic cancer patients

A. Casali, S. Santini, M. Della Giulia, L. Di Lauro, P. Vici, T. Gionfra, F. M. Sega

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Abstract

Twenty-six cancer patients (pts) with chemotherapy-related neutropenic fever were treated with vancomycin 30 mg/m2/day i.v. every 12 hrs, imipenem 1500 mg/day i.v. every 8 hrs, and pefloxacin 800 mg/day i.v. every 12 hrs. Twelve fevers of unknown origin (FUO), 10 gram-positive, 3 gram-negative and 1 mycoplasma were also treated. Globally, cure was observed in 22 pts (84%) and failure in 4 pts (16%); in gram-positive infections alone, cure was observed in 10 pts (80%) and failure in 4 pts (20%). Defervescence was obtained within 3 days in 77% pts. No relevant side effects were observed.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalJournal of Experimental and Clinical Cancer Research
Volume16
Issue number3
Publication statusPublished - Sep 1997

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Keywords

  • Defervescence
  • Imipenem
  • Infections
  • Pefloxacin
  • Vancomycin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Casali, A., Santini, S., Della Giulia, M., Di Lauro, L., Vici, P., Gionfra, T., & Sega, F. M. (1997). Triple combination antimicrobial regimen in the treatment of infections of neutropenic cancer patients. Journal of Experimental and Clinical Cancer Research, 16(3), 321-324.