Triple combination therapy to improve blood pressure control: Experience with olmesartan-amlodipine-hydrochlorothiazide therapy

Giuliano Tocci, Francesco Paneni, Jasmine Passerini, Massimo Volpe

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Effective treatment of hypertension is a key strategy for preventing and reducing the burden of hypertension-related cardiovascular diseases. In spite of these well-established concepts, hypertension remains poorly controlled, worldwide. Among the different pharmacological strategies required to improve blood pressure (BP) control, a more extensive use of combination therapy is progressively emerging as a cornerstone of a more effective treatment of hypertension. Among different drug combinations currently available for the clinical management of hypertension, those based on the association of drugs inhibiting the renin-angiotensin system, thiazide diuretics and calcium channel blockers have demonstrated to be very effective in lowering both systolic and diastolic, clinic and 24-h ambulatory BP levels with a good tolerability and safety profile. Areas covered: In the present manuscript the authors provide an overview of the evidence supporting the use of triple combination therapy with different classes of antihypertensive drugs, with a particular focus on those based on olmesartan medoxomil, a thiazide diuretic (hydrochlorothiazide) and a calcium channel blocker (amlodipine besylate). Expert opinion: Available data indicate that triple combination therapy based on olmesartan provides effective and sustained clinical and 24-h BP control in a high proportion of individuals among a broad range of hypertensive patients.

Original languageEnglish
Pages (from-to)2687-2697
Number of pages11
JournalExpert Opinion on Pharmacotherapy
Volume13
Issue number18
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Amlodipine besylate
  • Angiotensin receptor blocker
  • Blood pressure control
  • Calcium channel blocker
  • Hypertension
  • Olmesartan medoxomil
  • Thiazide diuretic
  • Triple combination therapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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