Triple dose of gadolinium-DTPA increases the sensitivity of spinal cord MRI in detecting enhancing lesions in multiple sclerosis

Tarek A. Yousry, Gunter Fesl, Ernst Walther, Raymond Voltz, Massimo Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the sensitivity of single and triple dose Gd-DTPA magnetic resonance imaging (MRI) in detecting enhancing lesions in the spinal cord of 13 patients with multiple sclerosis (MS). We detected two enhancing lesions in two of 13 (15%) patients when the single dose of Gd-DTPA was used and 12 lesions in five of 13 (38%) patients when the triple dose of Gd-DTPA was used. These results suggest that: (1) the use of triple dose increases the sensitivity of spinal cord MRI when studying relapsing-remitting or secondary progressive MS patients, (2) triple dose Gd-DTPA enhanced of the spinal cord MRI might be useful in monitoring disease activity in patients with MS.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalJournal of the Neurological Sciences
Volume158
Issue number2
DOIs
Publication statusPublished - Jun 30 1998

Keywords

  • Comparative studies
  • Contrast enhancement
  • Gadolinium-DTPA
  • Magnetic resonance
  • Multiple sclerosis
  • Spinal cord
  • Triple dose

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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