Triple Negative Breast Cancers Have a Reduced Expression of DNA Repair Genes

Enilze Ribeiro, Monica Ganzinelli, Daniele Andreis, Ramona Bertoni, Roberto Giardini, Stephen B. Fox, Massimo Broggini, Alberto Bottini, Vanessa Zanoni, Letizia Bazzola, Chiara Foroni, Daniele Generali, Giovanna Damia

Research output: Contribution to journalArticlepeer-review

Abstract

DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision, nucleotide excision, homologous recombination, and Fanconi anemia) in paraffin embedded samples of triple negative breast cancer (TNBC) compared to luminal A breast cancer (LABC). Most of the genes involved in nucleotide excision repair and Fanconi Anemia pathways, and CHK1 gene were significantly less expressed in TNBC than in LABC. PARP1 levels were higher in TNBC than in LABC. In univariate analysis high level of FANCA correlated with an increased overall survival and event free survival in TNBC; however multivariate analyses using Cox regression did not confirm FANCA as independent prognostic factor. These data support the evidence that TNBCs compared to LABCs harbour DNA repair defects.

Original languageEnglish
Article numbere66243
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 25 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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