ERADICAZIONE DELL'HELICOBACTER PYLORI: EFFICACIA DI UNA NUOVA TERAPIA TRIPLICE. STUDIO MULTICENTRICO CONTROLLATO CON AZITROMICINA PIU OMEPRAZOLO E AMOXICILLINA VERSUS OMEPRAZOLO PIU AMOXICILLINA

Translated title of the contribution: Triple therapy with omeprazole, amoxycillin and azitromycin is highly effective in the eradication of H. pylori infection - A multicenter controlled study versus dual therapy (amoxycillin and omeprazole)

G. Bertoni, R. Sassatelli, E. Nigrisoli, P. Tansini, G. Bianchi, G. Della Casa, A. Grisendi, G. Bedogni

Research output: Contribution to journalArticle

Abstract

Aim - To assess the efficacy of a new triple therapy based on omeprazole, amoxycillin and azitromycin for the eradication of H. pylori infection in patients with peptic ulcer or non-ulcer dyspepsia. Materials and methods - 96 patients with H. pylori positive peptic ulcer or non-ulcer dyspepsia were randomly assigned to one of the following two treatments: omeprazole 20 mg bid plus amoxycillin 1 g tid for 2 weeks or omeprazole 20 mg bid plus amoxycillin 1 g bid for 2 weeks plus azitromycin 500 mg uid during the first 3 days of therapy. H. pylori eradication was evaluated by means of urease rapid test and histology 6 weeks after stopping therapy. Results - 92 patients completed the treatment correctly. Eradication rates were 91.6% (44/48) in patients receiving triple therapy and 59.1% (26/44) in those treated with dual therapy (p <0.001). Frequency of side effects was similar in both groups of treatment (12.5% vs 9.1%). Conclusions - A two-week triple therapy with omeprazole 20 mg bid, amoxycillin 1 g bid and azitromycin 500 mg uid during the first 3 days is highly effective for the eradication of H. pylori infection, inducing eradication rates significantly higher to those obtained with the classical dual therapy (omperazole plus amoxycillin) with similar side effects.

Translated title of the contributionTriple therapy with omeprazole, amoxycillin and azitromycin is highly effective in the eradication of H. pylori infection - A multicenter controlled study versus dual therapy (amoxycillin and omeprazole)
Original languageItalian
Pages (from-to)55-61
Number of pages7
JournalArgomenti di Gastroenterologia Clinica
Volume9
Issue number3
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Gastroenterology

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