Triplication (/αααAnti3.7) or deletion (-α3.7/) association in Argentinian β-thalassemic carriers

I. M. Bragós; N. I. Noguera; M. P. Raviola; A. C. Milani

doi:10.1007/s00277-003-0738-6

Triplication (/αααAnti3.7) or deletion (-α3.7/) association in Argentinian β-thalassemic carriers

I. M. Bragós, N. I. Noguera, M. P. Raviola, A. C. Milani

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Prevalence of alpha gene triplication or deletion in β-thalassemia carriers was studied in 109 unrelated individuals in Rosario, Argentina. In different populations -α^3.7 allele presents a higher prevalence than ααα^anti3.7; thus, α-thalassemia associated with β-thalassemia is more frequently observed. Nevertheless, this event was detected in only one case (0.9%), while the association with alpha triplication was present in two subjects (1.8%).

Original language	English
Pages (from-to)	696-698
Number of pages	3
Journal	Annals of Hematology
Volume	82
Issue number	11
DOIs	https://doi.org/10.1007/s00277-003-0738-6
Publication status	Published - Nov 2003

Keywords

α-Gene triplication
α-Thalassemia
β-Thalassemia trait

ASJC Scopus subject areas

Hematology

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10.1007/s00277-003-0738-6

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title = "Triplication (/αααAnti3.7) or deletion (-α3.7/) association in Argentinian β-thalassemic carriers",

abstract = "Prevalence of alpha gene triplication or deletion in β-thalassemia carriers was studied in 109 unrelated individuals in Rosario, Argentina. In different populations -α3.7 allele presents a higher prevalence than αααanti3.7; thus, α-thalassemia associated with β-thalassemia is more frequently observed. Nevertheless, this event was detected in only one case (0.9%), while the association with alpha triplication was present in two subjects (1.8%).",

keywords = "α-Gene triplication, α-Thalassemia, β-Thalassemia trait",

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AU - Bragós, I. M.

AU - Noguera, N. I.

AU - Raviola, M. P.

AU - Milani, A. C.

PY - 2003/11

Y1 - 2003/11

N2 - Prevalence of alpha gene triplication or deletion in β-thalassemia carriers was studied in 109 unrelated individuals in Rosario, Argentina. In different populations -α3.7 allele presents a higher prevalence than αααanti3.7; thus, α-thalassemia associated with β-thalassemia is more frequently observed. Nevertheless, this event was detected in only one case (0.9%), while the association with alpha triplication was present in two subjects (1.8%).

AB - Prevalence of alpha gene triplication or deletion in β-thalassemia carriers was studied in 109 unrelated individuals in Rosario, Argentina. In different populations -α3.7 allele presents a higher prevalence than αααanti3.7; thus, α-thalassemia associated with β-thalassemia is more frequently observed. Nevertheless, this event was detected in only one case (0.9%), while the association with alpha triplication was present in two subjects (1.8%).

KW - α-Gene triplication

KW - α-Thalassemia

KW - β-Thalassemia trait

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Triplication (/αααAnti3.7) or deletion (-α3.7/) association in Argentinian β-thalassemic carriers

Abstract

Keywords

ASJC Scopus subject areas

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