Trisomy 12 and K-ras-2 amplification in human ovarian tumors

T. L. Yang-Feng, S. Li, W. Y. Leung, M. L. Carcangiu, P. E. Schwartz

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Cytogenetic analysis was performed on 11 benign and borderline ovarian tumors. Trisomy 12, identified as a sole abnormality in 6 tumors, is likely a specific karyotypic change in different benign and borderline tumors and may well be a primary chromosomal lesion in these tumors. The possible association between amplification of the proto-oncogene K-ras-2 which is located on chromosome 12 and trisomy 12 was investigated. DNA blotting analysis of 64 tumors indicates that trisomy 12 does not seem to be related to K-ras-2 amplification in ovarian tumors. K-ras-2 amplification was observed in 3 high-grade tumors from 3 patients with metastases.

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalInternational Journal of Cancer
Issue number5
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yang-Feng, T. L., Li, S., Leung, W. Y., Carcangiu, M. L., & Schwartz, P. E. (1991). Trisomy 12 and K-ras-2 amplification in human ovarian tumors. International Journal of Cancer, 48(5), 678-681.