Tritium labelled hyaluronic acid derivative

P. Orlando; G. de Sanctis; C. Giordano; G. Valle; R. la Bua; R. Ghidoni

doi:10.1002/jlcr.2580220913

Tritium labelled hyaluronic acid derivative

P. Orlando, G. de Sanctis, C. Giordano, G. Valle, R. la Bua, R. Ghidoni

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [³H]NaBH₄. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.

Original language	English
Pages (from-to)	961-969
Number of pages	9
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	22
Issue number	9
DOIs	https://doi.org/10.1002/jlcr.2580220913
Publication status	Published - 1985

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/jlcr.2580220913

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title = "Tritium labelled hyaluronic acid derivative",

abstract = "High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.",

author = "P. Orlando and {de Sanctis}, G. and C. Giordano and G. Valle and {la Bua}, R. and R. Ghidoni",

year = "1985",

doi = "10.1002/jlcr.2580220913",

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volume = "22",

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T1 - Tritium labelled hyaluronic acid derivative

AU - Orlando, P.

AU - de Sanctis, G.

AU - Giordano, C.

AU - Valle, G.

AU - la Bua, R.

AU - Ghidoni, R.

PY - 1985

Y1 - 1985

N2 - High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.

AB - High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.

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M3 - Article

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JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 9

ER -

Tritium labelled hyaluronic acid derivative

Abstract

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