Abstract
High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.
| Original language | English |
|---|---|
| Pages (from-to) | 961-969 |
| Number of pages | 9 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 22 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry
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Tritium labelled hyaluronic acid derivative. / Orlando, P.; de Sanctis, G.; Giordano, C.; Valle, G.; la Bua, R.; Ghidoni, R.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 22, No. 9, 1985, p. 961-969.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Tritium labelled hyaluronic acid derivative
AU - Orlando, P.
AU - de Sanctis, G.
AU - Giordano, C.
AU - Valle, G.
AU - la Bua, R.
AU - Ghidoni, R.
PY - 1985
Y1 - 1985
N2 - High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.
AB - High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.
UR - http://www.scopus.com/inward/record.url?scp=0021784167&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021784167&partnerID=8YFLogxK
U2 - 10.1002/jlcr.2580220913
DO - 10.1002/jlcr.2580220913
M3 - Article
AN - SCOPUS:0021784167
VL - 22
SP - 961
EP - 969
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
SN - 0362-4803
IS - 9
ER -