Tritium labelled hyaluronic acid derivative

P. Orlando, G. de Sanctis, C. Giordano, G. Valle, R. la Bua, R. Ghidoni

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.

Original languageEnglish
Pages (from-to)961-969
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume22
Issue number9
DOIs
Publication statusPublished - 1985

Fingerprint

Tritium
Hyaluronic Acid
Derivatives
Molecular Weight
Molecular weight
Radioactivity
Glycosaminoglycans
Purification
Infrared radiation
Oxidation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

Orlando, P., de Sanctis, G., Giordano, C., Valle, G., la Bua, R., & Ghidoni, R. (1985). Tritium labelled hyaluronic acid derivative. Journal of Labelled Compounds and Radiopharmaceuticals, 22(9), 961-969. https://doi.org/10.1002/jlcr.2580220913

Tritium labelled hyaluronic acid derivative. / Orlando, P.; de Sanctis, G.; Giordano, C.; Valle, G.; la Bua, R.; Ghidoni, R.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 22, No. 9, 1985, p. 961-969.

Research output: Contribution to journalArticle

Orlando, P, de Sanctis, G, Giordano, C, Valle, G, la Bua, R & Ghidoni, R 1985, 'Tritium labelled hyaluronic acid derivative', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 22, no. 9, pp. 961-969. https://doi.org/10.1002/jlcr.2580220913
Orlando P, de Sanctis G, Giordano C, Valle G, la Bua R, Ghidoni R. Tritium labelled hyaluronic acid derivative. Journal of Labelled Compounds and Radiopharmaceuticals. 1985;22(9):961-969. https://doi.org/10.1002/jlcr.2580220913
Orlando, P. ; de Sanctis, G. ; Giordano, C. ; Valle, G. ; la Bua, R. ; Ghidoni, R. / Tritium labelled hyaluronic acid derivative. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1985 ; Vol. 22, No. 9. pp. 961-969.
@article{25a45f757ceb450ba8d5b09b9738499b,
title = "Tritium labelled hyaluronic acid derivative",
abstract = "High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95{\%}.",
author = "P. Orlando and {de Sanctis}, G. and C. Giordano and G. Valle and {la Bua}, R. and R. Ghidoni",
year = "1985",
doi = "10.1002/jlcr.2580220913",
language = "English",
volume = "22",
pages = "961--969",
journal = "Journal of Labelled Compounds and Radiopharmaceuticals",
issn = "0362-4803",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

TY - JOUR

T1 - Tritium labelled hyaluronic acid derivative

AU - Orlando, P.

AU - de Sanctis, G.

AU - Giordano, C.

AU - Valle, G.

AU - la Bua, R.

AU - Ghidoni, R.

PY - 1985

Y1 - 1985

N2 - High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.

AB - High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.

UR - http://www.scopus.com/inward/record.url?scp=0021784167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021784167&partnerID=8YFLogxK

U2 - 10.1002/jlcr.2580220913

DO - 10.1002/jlcr.2580220913

M3 - Article

AN - SCOPUS:0021784167

VL - 22

SP - 961

EP - 969

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 9

ER -