Tritium labelled hyaluronic acid derivative

P. Orlando, G. de Sanctis, C. Giordano, G. Valle, R. la Bua, R. Ghidoni

Research output: Contribution to journalArticlepeer-review

Abstract

High molecular weight hyaluronic acid derivative was prepared in a radioactive form, labelled with tritium. The mucopolysaccharide was oxidized under mild conditions by sodium periodate. After purification the oxidation product was reduced with [3H]NaBH4. The tritium labelled hyaluronic acid derivative was obtained with a high specific radioactivity (0.15 mCi/mg) and was found to have similar physical and chemical characteristics (high molecular weight, infrared spectrum and electrophoretical behaviour) to the parent compound. The radiochemical purity of labelled hyaluronic acid derivative was found to be greater than 95%.

Original languageEnglish
Pages (from-to)961-969
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume22
Issue number9
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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