Triton WR 1339: Effect on the reticulo-endothelial system (RES) activity in tumor-bearing mice

G. Franchi, I. Reyers Degli Innocenti, S. Standen, S. Garattini

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The reticulo-endothelial system (RES) activity in normal and in intracerebral Sarcoma 180-bearing mice was investigated after acute or subchronic treatment with the non-ionic surface-active agent: Triton WR 1339 (TWR). While the single treatment is ineffective, the subchronic treatment markedly raises the phagocytic index not only in normal mice but also in tumor-bearing animals where the RES is depressed by the presence of disseminating cancer cells. A possible relation between the RES stimulatory capacity and the antimetastatic effect exerted by TWR is envisaged.

Original languageEnglish
Pages (from-to)487-490
Number of pages4
JournalEuropean Journal of Cancer (1965)
Issue number7
Publication statusPublished - 1973


ASJC Scopus subject areas

  • Oncology
  • Medicine(all)

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