TRITON WR 1339 (TWR), a formaldehyde polymer of polyoxyethylene ether of octylphenol, decreases the formation of lung metastases in C 57 B1/10 J/Sel mice transplanted in the leg with Lewis lung carcinoma, it reduces the number of lymph node metastases in Swiss albino mice transplanted intratibially with Ehrlich carcinoma and it reduces the number of cancer cells in the lung of Swiss albino mice transplanted intracerebrally with Sarcoma 180. These effects are achieved without any effect on the primary tumor. Furthermore TWR does not affect the growth of other tumors of the mice transplanted in different sites. Two main effects of TWR may be involved in its antimetastatic action: an effect on the host because TWR enhances the reticular endothelial system activity in tumor-bearing animals for foreign particles; an effect on the cancer cells because TWR, at concentrations present in vivo, affects the adhesiveness of cancer cells with an altered membrane, increases the volume, and decreases the movements of cancer cells. These effects may make in turn the cancer cells more susceptible to the defenses of the host. TWR is presented as the first example of antimetastatic agents differing from known antitumoral drugs also because it does not affect the primary tumor and the normal cells such as leukocytes.
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