Triton WR 1339 (TWR), an inhibitor of cancer dissemination and metastases

G. Franchi, L. Morasca, I. Reyers-Degli-Innocenti, S. Garattini

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

TRITON WR 1339 (TWR), a formaldehyde polymer of polyoxyethylene ether of octylphenol, decreases the formation of lung metastases in C 57 B1/10 J/Sel mice transplanted in the leg with Lewis lung carcinoma, it reduces the number of lymph node metastases in Swiss albino mice transplanted intratibially with Ehrlich carcinoma and it reduces the number of cancer cells in the lung of Swiss albino mice transplanted intracerebrally with Sarcoma 180. These effects are achieved without any effect on the primary tumor. Furthermore TWR does not affect the growth of other tumors of the mice transplanted in different sites. Two main effects of TWR may be involved in its antimetastatic action: an effect on the host because TWR enhances the reticular endothelial system activity in tumor-bearing animals for foreign particles; an effect on the cancer cells because TWR, at concentrations present in vivo, affects the adhesiveness of cancer cells with an altered membrane, increases the volume, and decreases the movements of cancer cells. These effects may make in turn the cancer cells more susceptible to the defenses of the host. TWR is presented as the first example of antimetastatic agents differing from known antitumoral drugs also because it does not affect the primary tumor and the normal cells such as leukocytes.

Original languageEnglish
JournalEuropean Journal of Cancer (1965)
Volume7
Issue number6
DOIs
Publication statusPublished - 1971

Fingerprint

Neoplasm Metastasis
Neoplasms
Sarcoma 180
Lewis Lung Carcinoma
tyloxapol
Adhesiveness
Lung
Ether
Formaldehyde
Cell Movement
Leg
Polymers
Leukocytes
Cell Count
Lymph Nodes
Carcinoma
Membranes
Growth
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Triton WR 1339 (TWR), an inhibitor of cancer dissemination and metastases. / Franchi, G.; Morasca, L.; Reyers-Degli-Innocenti, I.; Garattini, S.

In: European Journal of Cancer (1965), Vol. 7, No. 6, 1971.

Research output: Contribution to journalArticle

Franchi, G. ; Morasca, L. ; Reyers-Degli-Innocenti, I. ; Garattini, S. / Triton WR 1339 (TWR), an inhibitor of cancer dissemination and metastases. In: European Journal of Cancer (1965). 1971 ; Vol. 7, No. 6.
@article{f524cc80697c4330b9c790cb7dbad243,
title = "Triton WR 1339 (TWR), an inhibitor of cancer dissemination and metastases",
abstract = "TRITON WR 1339 (TWR), a formaldehyde polymer of polyoxyethylene ether of octylphenol, decreases the formation of lung metastases in C 57 B1/10 J/Sel mice transplanted in the leg with Lewis lung carcinoma, it reduces the number of lymph node metastases in Swiss albino mice transplanted intratibially with Ehrlich carcinoma and it reduces the number of cancer cells in the lung of Swiss albino mice transplanted intracerebrally with Sarcoma 180. These effects are achieved without any effect on the primary tumor. Furthermore TWR does not affect the growth of other tumors of the mice transplanted in different sites. Two main effects of TWR may be involved in its antimetastatic action: an effect on the host because TWR enhances the reticular endothelial system activity in tumor-bearing animals for foreign particles; an effect on the cancer cells because TWR, at concentrations present in vivo, affects the adhesiveness of cancer cells with an altered membrane, increases the volume, and decreases the movements of cancer cells. These effects may make in turn the cancer cells more susceptible to the defenses of the host. TWR is presented as the first example of antimetastatic agents differing from known antitumoral drugs also because it does not affect the primary tumor and the normal cells such as leukocytes.",
author = "G. Franchi and L. Morasca and I. Reyers-Degli-Innocenti and S. Garattini",
year = "1971",
doi = "10.1016/0014-2964(71)90059-4",
language = "English",
volume = "7",
journal = "European Journal of Cancer",
issn = "0014-2964",
publisher = "Elsevier Ltd",
number = "6",

}

TY - JOUR

T1 - Triton WR 1339 (TWR), an inhibitor of cancer dissemination and metastases

AU - Franchi, G.

AU - Morasca, L.

AU - Reyers-Degli-Innocenti, I.

AU - Garattini, S.

PY - 1971

Y1 - 1971

N2 - TRITON WR 1339 (TWR), a formaldehyde polymer of polyoxyethylene ether of octylphenol, decreases the formation of lung metastases in C 57 B1/10 J/Sel mice transplanted in the leg with Lewis lung carcinoma, it reduces the number of lymph node metastases in Swiss albino mice transplanted intratibially with Ehrlich carcinoma and it reduces the number of cancer cells in the lung of Swiss albino mice transplanted intracerebrally with Sarcoma 180. These effects are achieved without any effect on the primary tumor. Furthermore TWR does not affect the growth of other tumors of the mice transplanted in different sites. Two main effects of TWR may be involved in its antimetastatic action: an effect on the host because TWR enhances the reticular endothelial system activity in tumor-bearing animals for foreign particles; an effect on the cancer cells because TWR, at concentrations present in vivo, affects the adhesiveness of cancer cells with an altered membrane, increases the volume, and decreases the movements of cancer cells. These effects may make in turn the cancer cells more susceptible to the defenses of the host. TWR is presented as the first example of antimetastatic agents differing from known antitumoral drugs also because it does not affect the primary tumor and the normal cells such as leukocytes.

AB - TRITON WR 1339 (TWR), a formaldehyde polymer of polyoxyethylene ether of octylphenol, decreases the formation of lung metastases in C 57 B1/10 J/Sel mice transplanted in the leg with Lewis lung carcinoma, it reduces the number of lymph node metastases in Swiss albino mice transplanted intratibially with Ehrlich carcinoma and it reduces the number of cancer cells in the lung of Swiss albino mice transplanted intracerebrally with Sarcoma 180. These effects are achieved without any effect on the primary tumor. Furthermore TWR does not affect the growth of other tumors of the mice transplanted in different sites. Two main effects of TWR may be involved in its antimetastatic action: an effect on the host because TWR enhances the reticular endothelial system activity in tumor-bearing animals for foreign particles; an effect on the cancer cells because TWR, at concentrations present in vivo, affects the adhesiveness of cancer cells with an altered membrane, increases the volume, and decreases the movements of cancer cells. These effects may make in turn the cancer cells more susceptible to the defenses of the host. TWR is presented as the first example of antimetastatic agents differing from known antitumoral drugs also because it does not affect the primary tumor and the normal cells such as leukocytes.

UR - http://www.scopus.com/inward/record.url?scp=0015185572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015185572&partnerID=8YFLogxK

U2 - 10.1016/0014-2964(71)90059-4

DO - 10.1016/0014-2964(71)90059-4

M3 - Article

C2 - 4947215

AN - SCOPUS:0015185572

VL - 7

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0014-2964

IS - 6

ER -