TrkAIII: A novel hypoxia-regulated alternative TrkA splice variant of potential physiological and pathological importance

Antonella Tacconelli, Antonietta R. Farina, Lucia Cappabianca, Alberto Gulino, Andrew R. Mackay

Research output: Contribution to journalArticle

Abstract

Nerve growth factor receptor TrkA is critical for development and maturation of central and peripheral nervous systems, regulating proliferation, differentiation and apoptosis. In cancer, TrkA frequently exhibits suppressor activity in nonmutated form and oncogenic activity upon mutation. Our identification of a novel hypoxia-regulated alternative TrkAIII splice variant, expressed by neural crest-derived neuroblastic tumors, that exhibits neuroblastoma tumor promoting activity, adds significantly to our understanding of potential TrkA involvement in cancer. Our observation that hypoxia, which characterizes the tumor micro-environment, stimulates alternative TrkAIII splicing, provides a way by which TrkA tumor suppressing signals may convert to tumor promoting signals during progression and is consistent with conservation and pathological subversion by neural crest-derived neuroblastic tumors of a mechanism of potential physiological importance to normal neural stem/neural crest progenitors.

Original languageEnglish
Pages (from-to)8-9
Number of pages2
JournalCell Cycle
Volume4
Issue number1
Publication statusPublished - Jan 2005

Keywords

  • Hypoxia
  • Neuroblastoma neural stem cells
  • Splice variation
  • TrkA
  • Tumor progression

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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    Tacconelli, A., Farina, A. R., Cappabianca, L., Gulino, A., & Mackay, A. R. (2005). TrkAIII: A novel hypoxia-regulated alternative TrkA splice variant of potential physiological and pathological importance. Cell Cycle, 4(1), 8-9.