TROPHOBLAST CELLS IN PERIPHERAL BLOOD FROM PREGNANT WOMEN

A. E. Covone, P. M. Johnson, D. Mutton, M. Adinolfi

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of human trophoblast cells in maternal blood was investigated by the use offlow cytometry and a monoclonal antibody reacting against a specific antigen present on the surface of these cells. Three types of cells derived from the placenta could be detected in the peripheral blood obtained from women between 6 weeks' gestation and term. One group of cells were polynucleated, a second group were diploid, and a third consisted of anucleate cells derived from the syncytiotrophoblast. These cells should be suitable for prenatal diagnosis of chromosomal and biochemical abnormalities.

Original languageEnglish
Pages (from-to)841-843
Number of pages3
JournalLancet
Volume324
Issue number8407
DOIs
Publication statusPublished - Oct 13 1984

ASJC Scopus subject areas

  • Medicine(all)

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