TROPHOBLAST CELLS IN PERIPHERAL BLOOD FROM PREGNANT WOMEN

A. E. Covone; P. M. Johnson; D. Mutton; M. Adinolfi

doi:10.1016/S0140-6736(84)90875-4

TROPHOBLAST CELLS IN PERIPHERAL BLOOD FROM PREGNANT WOMEN

A. E. Covone, P. M. Johnson, D. Mutton, M. Adinolfi

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

The presence of human trophoblast cells in maternal blood was investigated by the use offlow cytometry and a monoclonal antibody reacting against a specific antigen present on the surface of these cells. Three types of cells derived from the placenta could be detected in the peripheral blood obtained from women between 6 weeks' gestation and term. One group of cells were polynucleated, a second group were diploid, and a third consisted of anucleate cells derived from the syncytiotrophoblast. These cells should be suitable for prenatal diagnosis of chromosomal and biochemical abnormalities.

Original language	English
Pages (from-to)	841-843
Number of pages	3
Journal	Lancet
Volume	324
Issue number	8407
DOIs	https://doi.org/10.1016/S0140-6736(84)90875-4
Publication status	Published - Oct 13 1984

ASJC Scopus subject areas

Medicine(all)

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title = "TROPHOBLAST CELLS IN PERIPHERAL BLOOD FROM PREGNANT WOMEN",

abstract = "The presence of human trophoblast cells in maternal blood was investigated by the use offlow cytometry and a monoclonal antibody reacting against a specific antigen present on the surface of these cells. Three types of cells derived from the placenta could be detected in the peripheral blood obtained from women between 6 weeks' gestation and term. One group of cells were polynucleated, a second group were diploid, and a third consisted of anucleate cells derived from the syncytiotrophoblast. These cells should be suitable for prenatal diagnosis of chromosomal and biochemical abnormalities.",

author = "Covone, {A. E.} and Johnson, {P. M.} and D. Mutton and M. Adinolfi",

year = "1984",

month = oct,

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volume = "324",

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AU - Covone, A. E.

AU - Johnson, P. M.

AU - Mutton, D.

AU - Adinolfi, M.

PY - 1984/10/13

Y1 - 1984/10/13

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AB - The presence of human trophoblast cells in maternal blood was investigated by the use offlow cytometry and a monoclonal antibody reacting against a specific antigen present on the surface of these cells. Three types of cells derived from the placenta could be detected in the peripheral blood obtained from women between 6 weeks' gestation and term. One group of cells were polynucleated, a second group were diploid, and a third consisted of anucleate cells derived from the syncytiotrophoblast. These cells should be suitable for prenatal diagnosis of chromosomal and biochemical abnormalities.

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