Troponin I in the intensive care unit setting: From the heart to the heart

Chiara Lazzeri, Manuela Bonizzoli, Giovanni Cianchi, Gian Franco Gensini, Adriano Peris

Research output: Contribution to journalArticle

Abstract

When measured in the plasma, cardiac troponins T (cTnT) and I (cTnI) are considered to be highly specific markers of myocardial cell damage; however, research has demonstrated that troponin elevation may associated with causes other than coronary artery disease. In the intensive care unit (ICU) setting, increased cTnI levels are quite common findings and when documented, even on admission, intensivists should bear in mind that this laboratory finding holds a prognostic role independent of the reason for ICU admission. The mechanism(s) (such as demand ischemia, myocardial strain, etc.) and not simply the cause (i.e., renal failure) of the increment in serum cTnI should be investigated to better tailor the therapeutical regimen in the single patient. In this review, we therefore consider the nonthrombotic causes of troponin elevation in the critical setting.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalInternal and Emergency Medicine
Volume3
Issue number1
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Troponin
Troponin I
Intensive Care Units
Troponin T
Renal Insufficiency
Myocardial Ischemia
Coronary Artery Disease
Serum
Research

Keywords

  • Critically ill
  • Intensive care unit
  • Sepsis
  • Trauma
  • Troponin

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine

Cite this

Troponin I in the intensive care unit setting : From the heart to the heart. / Lazzeri, Chiara; Bonizzoli, Manuela; Cianchi, Giovanni; Gensini, Gian Franco; Peris, Adriano.

In: Internal and Emergency Medicine, Vol. 3, No. 1, 03.2008, p. 9-16.

Research output: Contribution to journalArticle

Lazzeri, C, Bonizzoli, M, Cianchi, G, Gensini, GF & Peris, A 2008, 'Troponin I in the intensive care unit setting: From the heart to the heart', Internal and Emergency Medicine, vol. 3, no. 1, pp. 9-16. https://doi.org/10.1007/s11739-008-0089-3
Lazzeri, Chiara ; Bonizzoli, Manuela ; Cianchi, Giovanni ; Gensini, Gian Franco ; Peris, Adriano. / Troponin I in the intensive care unit setting : From the heart to the heart. In: Internal and Emergency Medicine. 2008 ; Vol. 3, No. 1. pp. 9-16.
@article{ebe460b6a4cb45169cbf954b6f7c0a23,
title = "Troponin I in the intensive care unit setting: From the heart to the heart",
abstract = "When measured in the plasma, cardiac troponins T (cTnT) and I (cTnI) are considered to be highly specific markers of myocardial cell damage; however, research has demonstrated that troponin elevation may associated with causes other than coronary artery disease. In the intensive care unit (ICU) setting, increased cTnI levels are quite common findings and when documented, even on admission, intensivists should bear in mind that this laboratory finding holds a prognostic role independent of the reason for ICU admission. The mechanism(s) (such as demand ischemia, myocardial strain, etc.) and not simply the cause (i.e., renal failure) of the increment in serum cTnI should be investigated to better tailor the therapeutical regimen in the single patient. In this review, we therefore consider the nonthrombotic causes of troponin elevation in the critical setting.",
keywords = "Critically ill, Intensive care unit, Sepsis, Trauma, Troponin",
author = "Chiara Lazzeri and Manuela Bonizzoli and Giovanni Cianchi and Gensini, {Gian Franco} and Adriano Peris",
year = "2008",
month = "3",
doi = "10.1007/s11739-008-0089-3",
language = "English",
volume = "3",
pages = "9--16",
journal = "Internal and Emergency Medicine",
issn = "1828-0447",
publisher = "Springer-Verlag Italia s.r.l.",
number = "1",

}

TY - JOUR

T1 - Troponin I in the intensive care unit setting

T2 - From the heart to the heart

AU - Lazzeri, Chiara

AU - Bonizzoli, Manuela

AU - Cianchi, Giovanni

AU - Gensini, Gian Franco

AU - Peris, Adriano

PY - 2008/3

Y1 - 2008/3

N2 - When measured in the plasma, cardiac troponins T (cTnT) and I (cTnI) are considered to be highly specific markers of myocardial cell damage; however, research has demonstrated that troponin elevation may associated with causes other than coronary artery disease. In the intensive care unit (ICU) setting, increased cTnI levels are quite common findings and when documented, even on admission, intensivists should bear in mind that this laboratory finding holds a prognostic role independent of the reason for ICU admission. The mechanism(s) (such as demand ischemia, myocardial strain, etc.) and not simply the cause (i.e., renal failure) of the increment in serum cTnI should be investigated to better tailor the therapeutical regimen in the single patient. In this review, we therefore consider the nonthrombotic causes of troponin elevation in the critical setting.

AB - When measured in the plasma, cardiac troponins T (cTnT) and I (cTnI) are considered to be highly specific markers of myocardial cell damage; however, research has demonstrated that troponin elevation may associated with causes other than coronary artery disease. In the intensive care unit (ICU) setting, increased cTnI levels are quite common findings and when documented, even on admission, intensivists should bear in mind that this laboratory finding holds a prognostic role independent of the reason for ICU admission. The mechanism(s) (such as demand ischemia, myocardial strain, etc.) and not simply the cause (i.e., renal failure) of the increment in serum cTnI should be investigated to better tailor the therapeutical regimen in the single patient. In this review, we therefore consider the nonthrombotic causes of troponin elevation in the critical setting.

KW - Critically ill

KW - Intensive care unit

KW - Sepsis

KW - Trauma

KW - Troponin

UR - http://www.scopus.com/inward/record.url?scp=52249090233&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52249090233&partnerID=8YFLogxK

U2 - 10.1007/s11739-008-0089-3

DO - 10.1007/s11739-008-0089-3

M3 - Article

C2 - 18324359

AN - SCOPUS:52249090233

VL - 3

SP - 9

EP - 16

JO - Internal and Emergency Medicine

JF - Internal and Emergency Medicine

SN - 1828-0447

IS - 1

ER -