Troponin T, troponin I and creatine kinase-MB mass after elective coronary stenting

Luigi La Vecchia, Francesco Bedogni, Giuseppe Finocchi, Gabriella Mezzena, Manuela Martini, Maurizio Sartori, Antonio Castellani, Guiliano Soffiati, Mario Vincenzi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess whether and to what extent elective coronary stenting is associated with biochemical evidence of minor myocardial damage (MMD), as defined by the detection of abnormal post-procedural serum levels of one or more among the following markers of ischaemic injury: creatine kinase (CK)-MB mass, troponin T (Tn-T) and troponin I (Tn-I). Methods: Nineteen elective procedures of coronary stenting were compared with a matched group of 25 conventional percutaneous transluminal coronary angioplasty (PTCA) procedures performed in our laboratory from March to June 1995. Cases with evolving or recent (<2 weeks) myocardial infarction, chronic total occlusions and dilatation of saphenous vein grafts were excluded. By definition, all of the patients had undergone uneventful deployment of a single Palmaz-Schatz stent, with no chest pain and no persistent EGG changes after the procedure. Serum levels of CK-MB mass, Tn-T and Tn-I were determined at baseline and 6, 12 and 24 h after the procedure. The frequency of abnormal results was determined for each marker. Baseline and peak post-procedural levels in the two groups were compared and related to procedural variables. Results: Baseline values were normal in all cases. The quantitative analysis showed that post-procedural levels of each marker (including total CK) were significantly higher with respect to baseline in both groups. In the stent group, two patients had positive CK-MB mass, four positive Tn-T and seven positive Tn-I. Absolute changes in Tn-T and Tn-I were closely related to changes in CK-MB mass (r = 0.76, P

Original languageEnglish
Pages (from-to)535-540
Number of pages6
JournalCoronary Artery Disease
Volume7
Issue number7
Publication statusPublished - 1996

Keywords

  • creatine kinase-MS mass
  • ischaemic injury
  • Palmaz-Schatz stent
  • side-branch occlusion
  • troponin I
  • troponin T

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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