TY - JOUR
T1 - TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice
AU - Marrone, Maria Cristina
AU - Morabito, Annunziato
AU - Giustizieri, Michela
AU - Chiurchiù, Valerio
AU - Leuti, Alessandro
AU - Mattioli, Marzia
AU - Marinelli, Sara
AU - Riganti, Loredana
AU - Lombardi, Marta
AU - Murana, Emanuele
AU - Totaro, Antonio
AU - Piomelli, Daniele
AU - Ragozzino, Davide
AU - Oddi, Sergio
AU - Maccarrone, Mauro
AU - Verderio, Claudia
AU - Marinelli, Silvia
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glutamatergic transmission in neurons by promoting extracellular microglial microvesicles shedding. Conversely, in the cortex of mice suffering from neuropathic pain, TRPV1 is also present in neurons affecting their intrinsic electrical properties and synaptic strength. Altogether, these findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication.
AB - The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glutamatergic transmission in neurons by promoting extracellular microglial microvesicles shedding. Conversely, in the cortex of mice suffering from neuropathic pain, TRPV1 is also present in neurons affecting their intrinsic electrical properties and synaptic strength. Altogether, these findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication.
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UR - http://www.scopus.com/inward/citedby.url?scp=85026197255&partnerID=8YFLogxK
U2 - 10.1038/ncomms15292
DO - 10.1038/ncomms15292
M3 - Article
AN - SCOPUS:85026197255
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 15292
ER -