TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchiù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana, Antonio Totaro, Daniele Piomelli, Davide Ragozzino, Sergio Oddi, Mauro Maccarrone, Claudia Verderio, Silvia Marinelli

Research output: Contribution to journalArticle

Abstract

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glutamatergic transmission in neurons by promoting extracellular microglial microvesicles shedding. Conversely, in the cortex of mice suffering from neuropathic pain, TRPV1 is also present in neurons affecting their intrinsic electrical properties and synaptic strength. Altogether, these findings identify brain TRPV1 as potential detector of harmful stimuli and a key player of microglia to neuron communication.

Original languageEnglish
Pages (from-to)15292
JournalNature Communications
Volume8
DOIs
Publication statusPublished - May 10 2017

Keywords

  • Journal Article

Fingerprint Dive into the research topics of 'TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice'. Together they form a unique fingerprint.

  • Cite this

    Marrone, M. C., Morabito, A., Giustizieri, M., Chiurchiù, V., Leuti, A., Mattioli, M., Marinelli, S., Riganti, L., Lombardi, M., Murana, E., Totaro, A., Piomelli, D., Ragozzino, D., Oddi, S., Maccarrone, M., Verderio, C., & Marinelli, S. (2017). TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice. Nature Communications, 8, 15292. https://doi.org/10.1038/ncomms15292