Truncated pre-S/S proteins transactivate multiple target sequences.

G. Natoli, C. Balsano, M. L. Avantaggiati, E. De Marzio, M. Artini, D. Collepardo, E. Elfassi, M. Levrero

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In order to investigate the transactivational function of HBV truncated preS/S proteins we have constructed two sets of plasmids and have tested their transactivational potential on the c-myc regulatory sequences and the TPA-responsive element. We found that preS/S proteins only become transactivationally active when truncated at the carboxy terminal end. Furthermore, using immunofluorescence microscopy we determined that the proteins are located exclusively in the cytoplasm, apparently ruling out DNA binding and activation of factors in the nucleus.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalArchives of virology. Supplementum
Volume4
Publication statusPublished - 1992

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Protein S
Fluorescence Microscopy
Cytoplasm
Plasmids
DNA
Proteins
protein S precursor

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Natoli, G., Balsano, C., Avantaggiati, M. L., De Marzio, E., Artini, M., Collepardo, D., ... Levrero, M. (1992). Truncated pre-S/S proteins transactivate multiple target sequences. Archives of virology. Supplementum, 4, 65-69.

Truncated pre-S/S proteins transactivate multiple target sequences. / Natoli, G.; Balsano, C.; Avantaggiati, M. L.; De Marzio, E.; Artini, M.; Collepardo, D.; Elfassi, E.; Levrero, M.

In: Archives of virology. Supplementum, Vol. 4, 1992, p. 65-69.

Research output: Contribution to journalArticle

Natoli, G, Balsano, C, Avantaggiati, ML, De Marzio, E, Artini, M, Collepardo, D, Elfassi, E & Levrero, M 1992, 'Truncated pre-S/S proteins transactivate multiple target sequences.', Archives of virology. Supplementum, vol. 4, pp. 65-69.
Natoli G, Balsano C, Avantaggiati ML, De Marzio E, Artini M, Collepardo D et al. Truncated pre-S/S proteins transactivate multiple target sequences. Archives of virology. Supplementum. 1992;4:65-69.
Natoli, G. ; Balsano, C. ; Avantaggiati, M. L. ; De Marzio, E. ; Artini, M. ; Collepardo, D. ; Elfassi, E. ; Levrero, M. / Truncated pre-S/S proteins transactivate multiple target sequences. In: Archives of virology. Supplementum. 1992 ; Vol. 4. pp. 65-69.
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