Truncated pre-S/S proteins transactivate multiple target sequences.

G. Natoli, C. Balsano, M. L. Avantaggiati, E. De Marzio, M. Artini, D. Collepardo, E. Elfassi, M. Levrero

Research output: Contribution to journalArticlepeer-review


In order to investigate the transactivational function of HBV truncated preS/S proteins we have constructed two sets of plasmids and have tested their transactivational potential on the c-myc regulatory sequences and the TPA-responsive element. We found that preS/S proteins only become transactivationally active when truncated at the carboxy terminal end. Furthermore, using immunofluorescence microscopy we determined that the proteins are located exclusively in the cytoplasm, apparently ruling out DNA binding and activation of factors in the nucleus.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalArchives of virology. Supplementum
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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