Tryptase- and leptin-positive mast cells correlate with vascular density in uterine leiomyomas

Domenico Ribatti, Anna S. Belloni, Beatrice Nico, Giorgia Salà, Vito Longo, Domenica Mangieri, Enrico Crivellato, Gastone G. Nussdorfer

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: In vitro and in vivo studies have linked mast cell (MC) degranulation and activation with angiogenesis and neovascularization. This assumption is partially supported by the close anatomical association between MC and the vasculature and the recruitment of these cells during tumor growth. The aim of this study was to correlate the extent of angiogenesis with the number of MC expressing tryptase and leptin in human leiomyomas. Study Design: Tissues from human leiomyomas and control specimens were investigated immunohistochemically, using murine monoclonal antibodies against the endothelial cell marker CD31, leptin, and the MC marker tryptase. Results: Angiogenesis, measured as microvessel counts, was highly correlated with MC tryptase- and leptin-positive cell counts. Conclusion: These data suggest that angiogenesis in leiomyomas is correlated to expression of tryptase in MC granules and provide for the first time evidence of a putative role of leptin, also contained in MC secretory granules, in MC-dependent angiogenesis.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • angiogenesis
  • leptin
  • leyomiomas
  • mast cells
  • tryptase

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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