Tryptase-positive mast cells and CD8-positive T cells in human endometrial cancer

Domenico Ribatti, Beatrice Nico, Nicoletta Finato, Enrico Crivellato

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, we correlated the number of tryptase-reactive mast cells with the number of CD8-positive T cells in human endometrial adenocarcinoma biopsy specimens by means of immunohistochemical techniques. Results have shown that CD8-positive T cell counts correlate to tryptase-positive mast cell counts and that these parameters increase in accordance with the tumor progression of human endometrial carcinoma. These data suggest that inhibition of inflammation or manipulation of inflammatory resolution pathways may be a new therapeutic approach for the treatment of endometrial adenocarcinoma.

Original languageEnglish
Pages (from-to)442-444
Number of pages3
JournalPathology International
Volume61
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • CD19 B cells
  • CD8 T cells
  • Endometrial adenocarcinoma
  • Inflammation
  • Mast cells
  • Tumor progression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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