Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

Girolamo Ranieri, Michele Ammendola, Rosa Patruno, Giuseppe Celano, Francesco Alfredo Zito, Severino Montemurro, Addolorata Rella, Valentina Di Lecce, Cosmo Damiano Gadaleta, Giovanni Battista De Sarro, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Literature data indicate that mast cells (MCs) are involved in tumor angiogenesis due to the release of several pro-angiogenetic factors among which tryptase, a serine protease stored in MCs granules, is one of the most active. However, no data are available concerning the role of MCs in angiogenesis in primary human breast cancer. In this study, we have evaluated the correlations between the number of MCs positive to tryptase (MCDPT), the area occupied by MCs positive to tryptase (MCAPT) and microvascular density (MVD) and endothelial area (EA) in a series of 88 primary T1-3, N0-2 M0 female breast cancer, by means of immunohistochemistry and image analysis methods. Data demonstrated a significant (r = from 0.78 to 0.89; p-value from 0.001 to 0.002 by Pearson's analysis respectively) correlation between MCDPT, MCAPT, MVD, EA to each other. No correlation concerning MCDPT, MCAPT, MVD, EA and the main clinicopathological features was found. Our results suggest that tryptase-positive MCs play a role in breast cancer angiogenesis. In this context several tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new anti-angiogenetic approach.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalInternational Journal of Oncology
Volume35
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Angiogenesis
  • Breast cancer
  • Endothelial area
  • Mast cells
  • Microvascular density
  • Tryptase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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