Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: Markers for aggression

Stefano Comai, Antonella Bertazzo, Jeanne Vachon, Marc Daigle, Jean Toupin, Gilles Côté, Gustavo Turecki, Gabriella Gobbi

Research output: Contribution to journalArticle

Abstract

Aggressive behavior is one of the most challenging symptoms in psychiatry, and biological markers for aggression lack of large sample validations. Serotonin (5-HT) and other neuroactive compounds deriving from Tryptophan (Trp), including kynurenine (Kyn), have not yet been investigated in large cohorts of aggressive individuals to validate their potential as biomarkers of aggression.In 361 male inmates we measured serum levels of Trp, 5-hydroxytryptophan, 5-HT, Kyn, the ratios 5-HT/Trp * 1000 and Kyn/Trp * 1000, and performed Structured Clinical Interview for DSM-IV Axis-I and -II Disorders (SCID-I and -II), global assessment of functioning (GAF), and scales for aggressive behavior, impulsivity, adult attention-deficit/hyperactivity disorder (ADHD), and intelligent quotient (IQ).Aggressive compared to non-aggressive inmates exhibited lower Trp and Kyn serum levels but higher levels of 5-HT and 5-HT/Trp * 1000, higher levels of impulsivity and ADHD indices, lower IQ and GAF, higher prevalence of mood disorders, drug abuse/dependence, and borderline, conduct and antisocial behaviors. Interestingly, Kyn/Trp * 1000 was positively correlated to the number of severe aggressive acts (r = 0.593, P <0.001). After adjusting for confounding factors, logistic regression analysis indicated that 5-HT/Trp * 1000, antisocial behavior, and GAF were predictors of aggressive behavior. The model combining these three predictors had an area under the ROC curve of 0.851 (95% CI 0.806-0.895).This study indicates that while circulating Trp is reduced in aggressive individuals, the combination of biological (5-HT/Trp ratio) and psychopathological (antisocial behavior and GAF) markers discriminates between aggressive and non-aggressive behavior suggesting the potential of a multi-marker approach in psychiatry given the heterogenic nature of mental diseases.
Original languageEnglish
Pages (from-to)8 - 16
Number of pages9
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume70
DOIs
Publication statusPublished - Oct 3 2016

Fingerprint

Kynurenine
Aggression
Tryptophan
Serotonin
Impulsive Behavior
Attention Deficit Disorder with Hyperactivity
Substance-Related Disorders
Psychiatry
Biomarkers
5-Hydroxytryptophan
Serum
Mood Disorders
ROC Curve
Diagnostic and Statistical Manual of Mental Disorders
Area Under Curve
Logistic Models
Regression Analysis
Interviews

Keywords

  • Aggressive behavior
  • Biomarkers
  • Kynurenine
  • Serotonin
  • Tryptophan

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: Markers for aggression. / Comai, Stefano; Bertazzo, Antonella; Vachon, Jeanne; Daigle, Marc; Toupin, Jean; Côté, Gilles; Turecki, Gustavo; Gobbi, Gabriella.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 70, 03.10.2016, p. 8 - 16.

Research output: Contribution to journalArticle

Comai, Stefano ; Bertazzo, Antonella ; Vachon, Jeanne ; Daigle, Marc ; Toupin, Jean ; Côté, Gilles ; Turecki, Gustavo ; Gobbi, Gabriella. / Tryptophan via serotonin/kynurenine pathways abnormalities in a large cohort of aggressive inmates: Markers for aggression. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2016 ; Vol. 70. pp. 8 - 16.
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