TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma

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Abstract

Hypothyroidism remains a common late effect after irradiation of the neck/mediastinum for Hodgkins lymphoma (HL). We evaluated the protective effect of TSH suppression during neck/mediastinum irradiation. From 1998 to 2001, 14 consecutive euthyroid children were given, before and until the end of their radiotherapy on neck/mediastinum, L-thyroxine at TSH-suppressive doses. The 14 patients had adequate TSH suppression during irradiation in 8, inadequate in 6. The 8-year hypothyroidism-free-survival after irradiation was 75±15% for the former group, 0% for the latter (P=0.009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL.

Original languageEnglish
Pages (from-to)166-168
Number of pages3
JournalPediatric Blood and Cancer
Volume57
Issue number1
DOIs
Publication statusPublished - Jul 15 2011

Keywords

  • Hodgkin lymphoma radiotherapy
  • Hypothyroidism
  • Late effects
  • Thyroid

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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