Abstract
Hypothyroidism remains a common late effect after irradiation of the neck/mediastinum for Hodgkins lymphoma (HL). We evaluated the protective effect of TSH suppression during neck/mediastinum irradiation. From 1998 to 2001, 14 consecutive euthyroid children were given, before and until the end of their radiotherapy on neck/mediastinum, L-thyroxine at TSH-suppressive doses. The 14 patients had adequate TSH suppression during irradiation in 8, inadequate in 6. The 8-year hypothyroidism-free-survival after irradiation was 75±15% for the former group, 0% for the latter (P=0.009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL.
Original language | English |
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Pages (from-to) | 166-168 |
Number of pages | 3 |
Journal | Pediatric Blood and Cancer |
Volume | 57 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jul 15 2011 |
Keywords
- Hodgkin lymphoma radiotherapy
- Hypothyroidism
- Late effects
- Thyroid
ASJC Scopus subject areas
- Oncology
- Pediatrics, Perinatology, and Child Health
- Hematology