TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma

Maura Massimino; Lorenza Gandola; Emanuele Pignoli; Ettore Seregni; Alfonso Marchianò; Emilia Pecori; Serena Catania; Graziella Cefalo

doi:10.1002/pbc.22915

TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma

Maura Massimino, Lorenza Gandola, Emanuele Pignoli, Ettore Seregni, Alfonso Marchianò, Emilia Pecori, Serena Catania, Graziella Cefalo

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Hypothyroidism remains a common late effect after irradiation of the neck/mediastinum for Hodgkins lymphoma (HL). We evaluated the protective effect of TSH suppression during neck/mediastinum irradiation. From 1998 to 2001, 14 consecutive euthyroid children were given, before and until the end of their radiotherapy on neck/mediastinum, L-thyroxine at TSH-suppressive doses. The 14 patients had adequate TSH suppression during irradiation in 8, inadequate in 6. The 8-year hypothyroidism-free-survival after irradiation was 75±15% for the former group, 0% for the latter (P=0.009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL.

Original language	English
Pages (from-to)	166-168
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	57
Issue number	1
DOIs	https://doi.org/10.1002/pbc.22915
Publication status	Published - Jul 15 2011

Keywords

Hodgkin lymphoma radiotherapy
Hypothyroidism
Late effects
Thyroid

ASJC Scopus subject areas

Oncology
Pediatrics, Perinatology, and Child Health
Hematology

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10.1002/pbc.22915

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TSH suppression as a possible means of protection against hypothyroidism after irradiation for childhood Hodgkins lymphoma. / Massimino, Maura ; Gandola, Lorenza ; Pignoli, Emanuele ; Seregni, Ettore ; Marchianò, Alfonso ; Pecori, Emilia; Catania, Serena; Cefalo, Graziella.

In: Pediatric Blood and Cancer, Vol. 57, No. 1, 15.07.2011, p. 166-168.

Research output: Contribution to journal › Article › peer-review

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abstract = "Hypothyroidism remains a common late effect after irradiation of the neck/mediastinum for Hodgkins lymphoma (HL). We evaluated the protective effect of TSH suppression during neck/mediastinum irradiation. From 1998 to 2001, 14 consecutive euthyroid children were given, before and until the end of their radiotherapy on neck/mediastinum, L-thyroxine at TSH-suppressive doses. The 14 patients had adequate TSH suppression during irradiation in 8, inadequate in 6. The 8-year hypothyroidism-free-survival after irradiation was 75±15% for the former group, 0% for the latter (P=0.009). TSH suppression could have a protective effect on thyroid function as shown in a small group of patients with HL.",

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AU - Marchianò, Alfonso

AU - Pecori, Emilia

AU - Catania, Serena

AU - Cefalo, Graziella

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