TT virus infection in end-stage renal disease (ESRD)

Fabrizio Fabrizi, Paul Martin, Giovanna Lunghi, Francesco Locatelli

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

TT virus is a novel hepatitis-associated DNA virus that has been provisionally designated as transfusion-transmitted virus (TTV). Infection by TTV has been frequently demonstrated in humans. Few reports, however, have been published on the epidemiology of TTV infection in patients with ESRD. The prevalence of TTV in patients undergoing maintenance dialysis varies widely and various demographic, virologic or clinical features can explain these differences; in some series, the prevalence of TTV in HD was significantly higher than in control groups. Blood transfusion requirement and nosocomial transmission of TTV within dialysis units seem to be important in the diffusion of TTV in the HD setting; however, other routes of TTV acquisition may play a role. The clinical significance related to the presence of TTV in HD population remains unclear; it is possible that TTV may aggravate liver disease caused by hepatitis C virus (HCV) infection. The natural history of TTV in dialysis is an area of avide research, since TTV has a propensity for establishing long-term infection in HD patients. The possibility that TTV causes pathological changes outside the liver cannot be ruled out. Further studies are in progress to understand the natural history and the epidemiology of TTV infection in patients with ESRD.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalJournal of Nephrology
Volume14
Issue number2
Publication statusPublished - Mar 2001

Fingerprint

Torque teno virus
Virus Diseases
Chronic Kidney Failure
Dialysis
Natural History
Epidemiology
Satellite Viruses
DNA Viruses

Keywords

  • ESRD
  • Hemodialysis
  • Liver disease
  • TTV

ASJC Scopus subject areas

  • Nephrology

Cite this

TT virus infection in end-stage renal disease (ESRD). / Fabrizi, Fabrizio; Martin, Paul; Lunghi, Giovanna; Locatelli, Francesco.

In: Journal of Nephrology, Vol. 14, No. 2, 03.2001, p. 80-87.

Research output: Contribution to journalArticle

Fabrizi, F, Martin, P, Lunghi, G & Locatelli, F 2001, 'TT virus infection in end-stage renal disease (ESRD)', Journal of Nephrology, vol. 14, no. 2, pp. 80-87.
Fabrizi, Fabrizio ; Martin, Paul ; Lunghi, Giovanna ; Locatelli, Francesco. / TT virus infection in end-stage renal disease (ESRD). In: Journal of Nephrology. 2001 ; Vol. 14, No. 2. pp. 80-87.
@article{a5d1565b653a492a9e122dccf63def54,
title = "TT virus infection in end-stage renal disease (ESRD)",
abstract = "TT virus is a novel hepatitis-associated DNA virus that has been provisionally designated as transfusion-transmitted virus (TTV). Infection by TTV has been frequently demonstrated in humans. Few reports, however, have been published on the epidemiology of TTV infection in patients with ESRD. The prevalence of TTV in patients undergoing maintenance dialysis varies widely and various demographic, virologic or clinical features can explain these differences; in some series, the prevalence of TTV in HD was significantly higher than in control groups. Blood transfusion requirement and nosocomial transmission of TTV within dialysis units seem to be important in the diffusion of TTV in the HD setting; however, other routes of TTV acquisition may play a role. The clinical significance related to the presence of TTV in HD population remains unclear; it is possible that TTV may aggravate liver disease caused by hepatitis C virus (HCV) infection. The natural history of TTV in dialysis is an area of avide research, since TTV has a propensity for establishing long-term infection in HD patients. The possibility that TTV causes pathological changes outside the liver cannot be ruled out. Further studies are in progress to understand the natural history and the epidemiology of TTV infection in patients with ESRD.",
keywords = "ESRD, Hemodialysis, Liver disease, TTV",
author = "Fabrizio Fabrizi and Paul Martin and Giovanna Lunghi and Francesco Locatelli",
year = "2001",
month = "3",
language = "English",
volume = "14",
pages = "80--87",
journal = "Journal of Nephrology",
issn = "1121-8428",
publisher = "Springer International Publishing",
number = "2",

}

TY - JOUR

T1 - TT virus infection in end-stage renal disease (ESRD)

AU - Fabrizi, Fabrizio

AU - Martin, Paul

AU - Lunghi, Giovanna

AU - Locatelli, Francesco

PY - 2001/3

Y1 - 2001/3

N2 - TT virus is a novel hepatitis-associated DNA virus that has been provisionally designated as transfusion-transmitted virus (TTV). Infection by TTV has been frequently demonstrated in humans. Few reports, however, have been published on the epidemiology of TTV infection in patients with ESRD. The prevalence of TTV in patients undergoing maintenance dialysis varies widely and various demographic, virologic or clinical features can explain these differences; in some series, the prevalence of TTV in HD was significantly higher than in control groups. Blood transfusion requirement and nosocomial transmission of TTV within dialysis units seem to be important in the diffusion of TTV in the HD setting; however, other routes of TTV acquisition may play a role. The clinical significance related to the presence of TTV in HD population remains unclear; it is possible that TTV may aggravate liver disease caused by hepatitis C virus (HCV) infection. The natural history of TTV in dialysis is an area of avide research, since TTV has a propensity for establishing long-term infection in HD patients. The possibility that TTV causes pathological changes outside the liver cannot be ruled out. Further studies are in progress to understand the natural history and the epidemiology of TTV infection in patients with ESRD.

AB - TT virus is a novel hepatitis-associated DNA virus that has been provisionally designated as transfusion-transmitted virus (TTV). Infection by TTV has been frequently demonstrated in humans. Few reports, however, have been published on the epidemiology of TTV infection in patients with ESRD. The prevalence of TTV in patients undergoing maintenance dialysis varies widely and various demographic, virologic or clinical features can explain these differences; in some series, the prevalence of TTV in HD was significantly higher than in control groups. Blood transfusion requirement and nosocomial transmission of TTV within dialysis units seem to be important in the diffusion of TTV in the HD setting; however, other routes of TTV acquisition may play a role. The clinical significance related to the presence of TTV in HD population remains unclear; it is possible that TTV may aggravate liver disease caused by hepatitis C virus (HCV) infection. The natural history of TTV in dialysis is an area of avide research, since TTV has a propensity for establishing long-term infection in HD patients. The possibility that TTV causes pathological changes outside the liver cannot be ruled out. Further studies are in progress to understand the natural history and the epidemiology of TTV infection in patients with ESRD.

KW - ESRD

KW - Hemodialysis

KW - Liver disease

KW - TTV

UR - http://www.scopus.com/inward/record.url?scp=0035036075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035036075&partnerID=8YFLogxK

M3 - Article

C2 - 11411018

AN - SCOPUS:0035036075

VL - 14

SP - 80

EP - 87

JO - Journal of Nephrology

JF - Journal of Nephrology

SN - 1121-8428

IS - 2

ER -