TT virus infection: Role of interferons, interleukin-28 and 29, cytokines and antiviral proteins

A. R. Garbuglia, F. Grasso, M. G. Donà, S. Mochi, P. Conti, M. A. De Lutiis, C. Giorgi, Teresa Iezzi

Research output: Contribution to journalArticle

Abstract

In 1997 a novel virus in the serum of a patient with acute post-transfusion hepatitis of non A-G etiology was identified. This agent was designed TT virus (TTV). It produces persistent viremia and no disease, but the mechanism of its persistence is poorly understood. In the present study mRNA expression of antiviral proteins as MxA, 2′ 5′ OAS, anti-apopotic protein, cytokines IL- 28, IL- 29 and IFN are examined in a subject affected by B lymphoma and positive for TTV DNA and RNA in this cellular subset, and in BJAB and Dohh2 cell lines.

Original languageEnglish
Pages (from-to)249-258
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume20
Issue number2
Publication statusPublished - Apr 2007

Keywords

  • Antiviral protein production
  • TTV infection

ASJC Scopus subject areas

  • Pharmacology

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