Tuberculosis contact investigation in low prevalence countries: A European consensus

C. G M Erkens, M. Kamphorst, I. Abubakar, G. H. Bothamley, D. Chemtob, W. Haas, G. B. Migliori, H. L. Rieder, J. P. Zellweger, C. Lange

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Contact investigation to identify individuals with tuberculosis and latent infection with Mycobacterium tuberculosis is an important component of tuberculosis control in low tuberculosis incidence countries. This document provides evidence-based and best-practice policy recommendations for contact tracing among high- and medium-priority contacts in a variety of settings. It provides a basis for national guidelines on contact investigation and tuberculosis outbreak management, and should support countries and tuberculosis control managers in evaluating and revising national policies. A review of existing guidelines, a literature search, several meetings and consultation with experts were used to formulate and grade recommendations for action during contact investigation. Available tests to identify individuals with latent infection with M. tuberculosis are designed to identify immune response against mycobacterial antigens and have variable predictive value for the likelihood to develop active tuberculosis in different populations. Contact investigation should therefore be limited to situations with a clear likelihood of transmission or to those with a higher probability of developing active tuberculosis, for instance, young children and immunocompromised persons. A risk assessment-based approach is recommended, where the need to screen contacts is prioritised on the basis of the infectiousness of the index case, intensity of exposure and susceptibility of contacts. Copyright

Original languageEnglish
Pages (from-to)925-949
Number of pages25
JournalEuropean Respiratory Journal
Volume36
Issue number4
DOIs
Publication statusPublished - Oct 1 2010

Fingerprint

Tuberculosis
Mycobacterium tuberculosis
Guidelines
Contact Tracing
Latent Tuberculosis
Evidence-Based Practice
Practice Guidelines
Disease Outbreaks
Referral and Consultation
Antigens
Incidence
Infection
Population

Keywords

  • Active case finding
  • Consensus statement
  • Contact investigation
  • Latent tuberculosis infection
  • Preventive chemotherapy
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Erkens, C. G. M., Kamphorst, M., Abubakar, I., Bothamley, G. H., Chemtob, D., Haas, W., ... Lange, C. (2010). Tuberculosis contact investigation in low prevalence countries: A European consensus. European Respiratory Journal, 36(4), 925-949. https://doi.org/10.1183/09031936.00201609

Tuberculosis contact investigation in low prevalence countries : A European consensus. / Erkens, C. G M; Kamphorst, M.; Abubakar, I.; Bothamley, G. H.; Chemtob, D.; Haas, W.; Migliori, G. B.; Rieder, H. L.; Zellweger, J. P.; Lange, C.

In: European Respiratory Journal, Vol. 36, No. 4, 01.10.2010, p. 925-949.

Research output: Contribution to journalArticle

Erkens, CGM, Kamphorst, M, Abubakar, I, Bothamley, GH, Chemtob, D, Haas, W, Migliori, GB, Rieder, HL, Zellweger, JP & Lange, C 2010, 'Tuberculosis contact investigation in low prevalence countries: A European consensus', European Respiratory Journal, vol. 36, no. 4, pp. 925-949. https://doi.org/10.1183/09031936.00201609
Erkens CGM, Kamphorst M, Abubakar I, Bothamley GH, Chemtob D, Haas W et al. Tuberculosis contact investigation in low prevalence countries: A European consensus. European Respiratory Journal. 2010 Oct 1;36(4):925-949. https://doi.org/10.1183/09031936.00201609
Erkens, C. G M ; Kamphorst, M. ; Abubakar, I. ; Bothamley, G. H. ; Chemtob, D. ; Haas, W. ; Migliori, G. B. ; Rieder, H. L. ; Zellweger, J. P. ; Lange, C. / Tuberculosis contact investigation in low prevalence countries : A European consensus. In: European Respiratory Journal. 2010 ; Vol. 36, No. 4. pp. 925-949.
@article{28dd3e9911cb4b389b72a23672f2ce08,
title = "Tuberculosis contact investigation in low prevalence countries: A European consensus",
abstract = "Contact investigation to identify individuals with tuberculosis and latent infection with Mycobacterium tuberculosis is an important component of tuberculosis control in low tuberculosis incidence countries. This document provides evidence-based and best-practice policy recommendations for contact tracing among high- and medium-priority contacts in a variety of settings. It provides a basis for national guidelines on contact investigation and tuberculosis outbreak management, and should support countries and tuberculosis control managers in evaluating and revising national policies. A review of existing guidelines, a literature search, several meetings and consultation with experts were used to formulate and grade recommendations for action during contact investigation. Available tests to identify individuals with latent infection with M. tuberculosis are designed to identify immune response against mycobacterial antigens and have variable predictive value for the likelihood to develop active tuberculosis in different populations. Contact investigation should therefore be limited to situations with a clear likelihood of transmission or to those with a higher probability of developing active tuberculosis, for instance, young children and immunocompromised persons. A risk assessment-based approach is recommended, where the need to screen contacts is prioritised on the basis of the infectiousness of the index case, intensity of exposure and susceptibility of contacts. Copyright",
keywords = "Active case finding, Consensus statement, Contact investigation, Latent tuberculosis infection, Preventive chemotherapy, Tuberculosis",
author = "Erkens, {C. G M} and M. Kamphorst and I. Abubakar and Bothamley, {G. H.} and D. Chemtob and W. Haas and Migliori, {G. B.} and Rieder, {H. L.} and Zellweger, {J. P.} and C. Lange",
year = "2010",
month = "10",
day = "1",
doi = "10.1183/09031936.00201609",
language = "English",
volume = "36",
pages = "925--949",
journal = "European Journal of Respiratory Diseases",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "4",

}

TY - JOUR

T1 - Tuberculosis contact investigation in low prevalence countries

T2 - A European consensus

AU - Erkens, C. G M

AU - Kamphorst, M.

AU - Abubakar, I.

AU - Bothamley, G. H.

AU - Chemtob, D.

AU - Haas, W.

AU - Migliori, G. B.

AU - Rieder, H. L.

AU - Zellweger, J. P.

AU - Lange, C.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Contact investigation to identify individuals with tuberculosis and latent infection with Mycobacterium tuberculosis is an important component of tuberculosis control in low tuberculosis incidence countries. This document provides evidence-based and best-practice policy recommendations for contact tracing among high- and medium-priority contacts in a variety of settings. It provides a basis for national guidelines on contact investigation and tuberculosis outbreak management, and should support countries and tuberculosis control managers in evaluating and revising national policies. A review of existing guidelines, a literature search, several meetings and consultation with experts were used to formulate and grade recommendations for action during contact investigation. Available tests to identify individuals with latent infection with M. tuberculosis are designed to identify immune response against mycobacterial antigens and have variable predictive value for the likelihood to develop active tuberculosis in different populations. Contact investigation should therefore be limited to situations with a clear likelihood of transmission or to those with a higher probability of developing active tuberculosis, for instance, young children and immunocompromised persons. A risk assessment-based approach is recommended, where the need to screen contacts is prioritised on the basis of the infectiousness of the index case, intensity of exposure and susceptibility of contacts. Copyright

AB - Contact investigation to identify individuals with tuberculosis and latent infection with Mycobacterium tuberculosis is an important component of tuberculosis control in low tuberculosis incidence countries. This document provides evidence-based and best-practice policy recommendations for contact tracing among high- and medium-priority contacts in a variety of settings. It provides a basis for national guidelines on contact investigation and tuberculosis outbreak management, and should support countries and tuberculosis control managers in evaluating and revising national policies. A review of existing guidelines, a literature search, several meetings and consultation with experts were used to formulate and grade recommendations for action during contact investigation. Available tests to identify individuals with latent infection with M. tuberculosis are designed to identify immune response against mycobacterial antigens and have variable predictive value for the likelihood to develop active tuberculosis in different populations. Contact investigation should therefore be limited to situations with a clear likelihood of transmission or to those with a higher probability of developing active tuberculosis, for instance, young children and immunocompromised persons. A risk assessment-based approach is recommended, where the need to screen contacts is prioritised on the basis of the infectiousness of the index case, intensity of exposure and susceptibility of contacts. Copyright

KW - Active case finding

KW - Consensus statement

KW - Contact investigation

KW - Latent tuberculosis infection

KW - Preventive chemotherapy

KW - Tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=77956599594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956599594&partnerID=8YFLogxK

U2 - 10.1183/09031936.00201609

DO - 10.1183/09031936.00201609

M3 - Article

C2 - 20889463

AN - SCOPUS:77956599594

VL - 36

SP - 925

EP - 949

JO - European Journal of Respiratory Diseases

JF - European Journal of Respiratory Diseases

SN - 0903-1936

IS - 4

ER -