Abstract
Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-γ secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-γ. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.
Original language | English |
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Pages (from-to) | 449-452 |
Number of pages | 4 |
Journal | Diagnostic Microbiology and Infectious Disease |
Volume | 71 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 2011 |
Keywords
- HBHA
- IFN
- TNF
- Tuberculosis
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases