Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis

Paola Molicotti, Alessandra Bua, Marina Cubeddu, Sara Cannas, Giovanni Delogu, Stefania Zanetti

Research output: Contribution to journalArticlepeer-review

Abstract

Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-γ secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-γ. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume71
Issue number4
DOIs
Publication statusPublished - Dec 2011

Keywords

  • HBHA
  • IFN
  • TNF
  • Tuberculosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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