Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis

Paola Molicotti; Alessandra Bua; Marina Cubeddu; Sara Cannas; Giovanni Delogu; Stefania Zanetti

doi:10.1016/j.diagmicrobio.2011.08.010

Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis

Paola Molicotti, Alessandra Bua, Marina Cubeddu, Sara Cannas, Giovanni Delogu, Stefania Zanetti

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-γ secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-γ. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.

Original language	English
Pages (from-to)	449-452
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	71
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2011.08.010
Publication status	Published - Dec 2011

Keywords

HBHA
IFN
TNF
Tuberculosis

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2011.08.010

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Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis. / Molicotti, Paola; Bua, Alessandra; Cubeddu, Marina; Cannas, Sara; Delogu, Giovanni; Zanetti, Stefania.

In: Diagnostic Microbiology and Infectious Disease, Vol. 71, No. 4, 12.2011, p. 449-452.

Research output: Contribution to journal › Article › peer-review

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abstract = "Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-γ secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-γ. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.",

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AU - Delogu, Giovanni

AU - Zanetti, Stefania

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Tuberculosis patients are characterized by a low-IFN-γ/high-TNF-γ response to methylated HBHA produced in M. smegmatis

Abstract

Keywords

ASJC Scopus subject areas

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