Whole blood from Mycobacterium tuberculosis-infected subjects was stimulated with heparin-binding hemagglutinin (HBHA). Tuberculosis (TB) patients showed an HBHA-specific T-cell response characterized by low-IFN-γ/high-TNF-γ secretion, while asymptomatic subjects with latent infection (LTBI) and TB patients under therapy showed a pattern with high IFN-γ/low TNF-γ. These results underscore the usefulness of HBHA in helping to distinguish LTBI subjects versus TB patients.
|Number of pages||4|
|Journal||Diagnostic Microbiology and Infectious Disease|
|Publication status||Published - Dec 2011|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases