Tug of war between survival and death: Exploring ATM function in cancer

Venturina Stagni, Veronica Oropallo, Giulia Fianco, Martina Antonelli, Irene Cinà, Daniela Barilà

Research output: Contribution to journalArticle

Abstract

Ataxia-telangiectasia mutated (ATM) kinase is a one of the main guardian of genome stability and plays a central role in the DNA damage response (DDR). The deregulation of these pathways is strongly linked to cancer initiation and progression as well as to the development of therapeutic approaches. These observations, along with reports that identify ATM loss of function as an event that may promote tumor initiation and progression, point to ATM as a bona fide tumor suppressor. The identification of ATM as a positive modulator of several signalling networks that sustain tumorigenesis, including oxidative stress, hypoxia, receptor tyrosine kinase and AKT serine-threonine kinase activation, raise the question of whether ATM function in cancer may be more complex. This review aims to give a complete overview on the work of several labs that links ATM to the control of the balance between cell survival, proliferation and death in cancer.

Original languageEnglish
Pages (from-to)5388-5409
Number of pages22
JournalInternational Journal of Molecular Sciences
Volume15
Issue number4
DOIs
Publication statusPublished - Mar 27 2014

Keywords

  • Apoptosis
  • ATM kinase
  • Cancer development and therapy
  • Death receptors
  • DNA damage response (DDR)
  • Hypoxia and angiogenesis
  • Oxidative stress
  • Receptor tyrosine kinase
  • Stem cells

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Medicine(all)

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